Results 31 to 40 of about 775,328 (297)

The utility of ctDNA in detecting minimal residual disease following curative surgery in colorectal cancer: a systematic review and meta-analysis

British Journal of Cancer, 2022
Introduction Colorectal cancer is the fourth most common cancer in the UK. There remains a need for improved risk stratification following curative resection.
L. Faulkner, L. Howells, C. Pepper, J. Shaw, Abin Varghese Thomas   +4 more
semanticscholar   +1 more source

Detection of minimal residual disease following induction immunochemotherapy predicts progression free survival in mantle cell lymphoma: final results of CALGB 59909

Haematologica, 2012
Background In the present study, the prognostic impact of minimal residual disease during treatment on time to progression and overall survival was analyzed prospectively in patients with mantle cell lymphoma treated on the Cancer and Leukemia Group B ...
Hongtao Liu, Jeffrey L. Johnson, Greg Koval, Greg Malnassy, Dorie Sher, Lloyd E. Damon, Eric D. Hsi, Donna Marie Bucci, Charles A. Linker, Bruce D. Cheson, Wendy Stock   +10 more
doaj   +1 more source

Clinical significance of novel subtypes of acute lymphoblastic leukemia in the context of minimal residual disease-directed therapy.

Blood Cancer Discovery, 2021
We evaluate clinical significance of recently identified subtypes of acute lymphoblastic leukemia (ALL) in 598 children treated with minimal residual disease (MRD)-directed therapy.
S. Jeha, J. Choi, K. Roberts, Deqing Pei, E. Coustan-Smith, H. Inaba, J. Rubnitz, R. Ribeiro, T. Gruber, S. Raimondi, Seth E. Karol, Chunxu Qu, Samuel W. Brady, Zhaohui Gu, Jun J. Yang, Cheng Cheng, J. Downing, W. Evans, M. Relling, D. Campana, C. Mullighan, C. Pui   +21 more
semanticscholar   +1 more source

Which are the most promising targets for minimal residual disease-directed therapy in acute myeloid leukemia prior to allogeneic stem cell transplant?

Haematologica, 2019
Minimal residual disease has emerged as an important prognostic factor for relapse and survival in acute myeloid leukemia. Eradication of minimal residual disease may increase the number of patients with long-term survival; however, to date, strategies ...
Brian Ball, Eytan M. Stein
doaj   +1 more source

Liquid biopsies and minimal residual disease in lymphoid malignancies

Frontiers in Oncology, 2023
Minimal residual disease (MRD) assessment using peripheral blood instead of bone marrow aspirate/biopsy specimen or the biopsy of the cancerous infiltrated by lymphoid malignancies is an emerging technique with enormous interest of research and ...
Maroun Bou Zerdan, Joseph Kassab, Ludovic Saba, Elio Haroun, Morgan Bou Zerdan, Sabine Allam, Lewis Nasr, Walid Macaron, Mahinbanu Mammadli, Sarah Abou Moussa, Chakra P. Chaulagain   +10 more
doaj   +1 more source

Mutations that permit residual CFTR function delay acquisition of multiple respiratory pathogens in CF patients [PDF]

, 2010
Background Lung infection by various organisms is a characteristic feature of cystic fibrosis (CF). CFTR genotype effects acquisition of Pseudomonas aeruginosa (Pa), however the effect on acquisition of other infectious organisms that frequently precede ...
Naughton Kathleen M, Henderson Lindsay B, Sosnay Patrick R, Blackman Scott M, McDougal Kathryn E, Green Deanna M, Collaco J Michael, Cutting Garry R   +7 more
core   +2 more sources

Prognostic value of minimal residual disease negativity in myeloma: combined analysis of POLLUX, CASTOR, ALCYONE, MAIA.

Blood, 2021
We explored minimal residual disease (MRD) in relapsed/refractory multiple myeloma (RRMM) and transplant-ineligible newly diagnosed multiple myeloma (TIE NDMM) using data from four phase 3 studies (POLLUX, CASTOR, ALCYONE, and MAIA).
M. Cavo, J. San-Miguel, S. Usmani, K. Weisel, M. Dimopoulos, H. Avet-Loiseau, B. Paiva, N. Bahlis, T. Plesner, V. Hungria, P. Moreau, M. Mateos, A. Perrot, S. Iida, T. Facon, Shaji K. Kumar, N. V. D. van de Donk, P. Sonneveld, A. Spencer, M. Krevvata, C. Heuck, Jianping Wang, J. Ukropec, R. Kobos, Steven Sun, M. Qi, N. Munshi   +26 more
semanticscholar   +1 more source

Minimal residual disease prior to allogeneic hematopoietic cell transplantation in acute myeloid leukemia: a meta-analysis [PDF]

, 2017
Minimal residual disease prior to allogeneic hematopoietic cell transplantation has been associated with increased risk of relapse and death in patients with acute myeloid leukemia, but detection methodologies and results vary widely.
Anthias, Chloe, Buccisano, Francesco, Buckley, Sarah A, Defor, Todd E, Devine, Beth, Gruhn, Bernd, Hourigan, Christopher S, Kanakry, Christopher G, Linden, Michael A, Malagola, Michele, Othus, Megan, Ustun, Celalettin, Valkova, Veronika, Walter, Roland B., Wood, Brent L   +14 more
core   +2 more sources

Sustained Minimal Residual Disease Negativity With Daratumumab in Newly Diagnosed Multiple Myeloma: MAIA and ALCYONE.

Blood, 2021
In patients with transplant-ineligible newly diagnosed multiple myeloma (NDMM), daratumumab reduced the risk of disease progression or death by 44% in MAIA (daratumumab/lenalidomide/dexamethasone; D-Rd) and 58% in ALCYONE (daratumumab/bortezomib ...
San Miguel Jesus, H. Avet-Loiseau, B. Paiva, Shaji K. Kumar, M. Dimopoulos, T. Facon, M. Mateos, C. Touzeau, A. Jakubowiak, S. Usmani, G. Cook, M. Cavo, H. Quach, J. Ukropec, P. Ramaswami, H. Pei, M. Qi, Steven Sun, Jianping Wang, M. Krevvata, Nikki A. Deangelis, C. Heuck, Rian Van Rampelbergh, Anupa Kudva, R. Kobos, M. Qi, N. Bahlis   +26 more
semanticscholar   +1 more source

Pre-transplantation minimal residual disease with cytogenetic and molecular diagnostic features improves risk stratification in acute myeloid leukemia

Haematologica, 2017
Our aim was to improve outcome prediction after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia by combining cytogenetic and molecular data at diagnosis with minimal residual disease assessment by multicolor flow-cytometry at
Betül Oran, Jeff L. Jorgensen, David Marin, Sa Wang, Sairah Ahmed, Amin M. Alousi, Borje S. Andersson, Qaiser Bashir, Roland Bassett, Genevieve Lyons, Julianne Chen, Katy Rezvani, Uday Popat, Partow Kebriaei, Keyur Patel, Gabriela Rondon, Elizabeth J. Shpall, Richard E. Champlin   +17 more
doaj   +1 more source