Results 91 to 100 of about 8,180 (214)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Mechanical and thermal responses of random triply periodic minimal surface structures

Materials & Design
This study investigates the mechanical and thermal responses of stochastic Triply Periodic Minimal Surface (TPMS) structures fabricated using the laser powder bed fusion process with Ti-6Al-4V.
Maytawee Maneein, Thanakit Yuthchaiming, Chutima Pankul, Atikom Sombatmai, Teerapong Poltue, Vikram Ahuja, Raj Das, Patcharapit Promoppatum   +7 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Validation of material-invariant mechanical models for triply periodic minimal surface structures

Results in Materials
Their dual functionality makes triply periodic minimal surface (TPMS) sheet networks an ideal candidate for permeable, load-bearing cellular structures. The present study investigates Gyroid and Primitive structures in quasi-static compression.
Henri Kammler, Jan Kube, Hendrik Traub, Christian Hühne   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Chamfer distance for non-linear registration of Triply Periodic Minimal Surface lattices

Additive Manufacturing Letters
We present a 3D image registration technique for non-linear deformation estimation in Additive Manufacturing processes. The methodology involves comparing X-ray Computed Tomography (XCT) data with Computer Aided Design (CAD) models for Triply Periodic ...
Michela Lapenna, Francesco Faglioni, Keerthana Chand, Bardia Hejazi, Rita Fioresi, Giovanni Bruno   +5 more
doaj   +1 more source

A Property of Minimal Surfaces [PDF]

Proceedings of the National Academy of Sciences, 1953
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Bulk metric reconstruction from entanglement data via minimal surface area variations

Journal of High Energy Physics
We investigate the reconstruction of asymptotically anti-de Sitter (AdS) bulk geometries from boundary entanglement entropy data for ball-shaped entangling regions.
Niko Jokela, Tony Liimatainen, Miika Sarkkinen, Leo Tzou   +3 more
doaj   +1 more source

Topological interface modes in 3D-printed triply periodic minimal surface phononic crystals

Materials & Design
Triply periodic minimal surface (TPMS)-based continuous structures have recently attracted increased attention due to their remarkable mechanical properties, such as high strength-to-weight ratio, impact resistance, and energy absorption capabilities. In
Prabhakaran Manogharan, Alper Erturk
doaj   +1 more source