Results 111 to 120 of about 224,803 (301)

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Diagnostic evaluation of patients with disorders of consciousness with diffusion tensor imaging

Chinese Neurosurgical Journal, 2017
Background With the development of emergency and intensive medical technologies, the survival rate of traumatic brain injury has greatly increased. More and more patients have been converted from severe coma to alleviated state of consciousness, which ...
Long Xu, Yi Yang, Er’an Guo, Xiaogang Tao, Te Lu, Runfa Tian, Zhu Chen, Xiaoyu Xia, Qingxia Tao, Mingmei Ge, Jianghong He, Jingsheng Li, Jizong Zhao   +12 more
doaj   +1 more source

Toward a Collectivist National Defense [PDF]

, 2020
Most philosophers writing on the ethics of war endorse “reductivist individualism,” a view that holds both that killing in war is subject to the very same principles of ordinary morality ; and that morality concerns individuals and their rights, and does
Davis, Jeremy
core  

Multimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy". [PDF]

, 2011
Beside behavioral assessment of patients with disorders of consciousness, neuroimaging modalities may offer objective paraclinical markers important for diagnosis and prognosis.
Andrews, Behrens, Benson, Brenner, Childs, Damasio, Damoiseaux, De Martino, Edelman, Fernández-Espejo, Fernández-Espejo, Formisano, Gazzaniga, Genovese, Giacino, Giacino, Gill-Thwaites, Huisman, Laureys, Laureys, Laureys, Laureys, Laureys, Le Bihan, Leclercq, Leon-Carrion, Majerus, Monti, Nakayama, Newcombe, Percival, Schnakers, Sherbondy, Sidaros, Smith, Teasdale, The Multi-Society Task Force on Pvs, Tshibanda, Tshibanda, Vanhaudenhuyse, Ylipaavalniem, Ylipaavalniemi, Zhang   +42 more
core   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Distinguish Patients in a Vegetative State from the Minimally Conscious state: moral and legal dilemmas

Revista de Bioética y Derecho, 2013
Research done using current neuroimaging techniques specifically, positron emission tomography (PET) and functional magnetic resonance imaging (functional MRI)—have provided evidence that vegetative patients may have fragments of consciousness.
Silvia Zullo
doaj   +1 more source

Multiscale Design of Dental Restorative Materials: Mechanistic Foundations, Technological Innovations, and Clinical Translation

Advanced Science, EarlyView.
From conventional ceramics to bioinspired smart composites, this review charts the evolution of dental restorative biomaterials. Integrating materials innovation, advanced manufacturing technologies, and bioinspired strategies, it presents a roadmap for developing functional, clinically translatable restorations that combine durability, adaptability ...
Bailei Li, Ruixue Ai, Xinjiani Chen, Yaning Wang, Chenlei Pan, Suxian Song, Chenjie Yang, Yu Zhou, Zhen Zhang, Xiaojun Liu, Xiaodi Liu, Liping Yao, Quanbao Zhang, Wenxue Gu, Rongqing Zhang   +14 more
wiley   +1 more source

Longitudinal Bedside Assessments of Brain Networks in Disorders of Consciousness: Case Reports From the Field

Frontiers in Neurology, 2018
Clinicians are regularly faced with the difficult challenge of diagnosing consciousness after severe brain injury. As such, as many as 40% of minimally conscious patients who demonstrate fluctuations in arousal and awareness are known to be misdiagnosed ...
Corinne A. Bareham, Judith Allanson, Neil Roberts, Peter J. A. Hutchinson, John D. Pickard, David K. Menon, Srivas Chennu, Srivas Chennu   +7 more
doaj   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Could Arterial Spin Labeling Distinguish Patients in Minimally Conscious State from Patients in Vegetative State?

Frontiers in Neurology, 2018
PurposeDiagnostic error is common among patients with vegetative state (VS) and minimally conscious state (MCS). The purpose of this article is to use three-dimensional pseudo-continuous arterial spin labeling (pcASL) to compare cerebral blood flow (CBF)
Bing Wu, Yi Yang, Shuai Zhou, Wei Wang, Zizhen Wang, Gang Hu, Jianghong He, Xinhuai Wu, Xinhuai Wu   +8 more
doaj   +1 more source