Results 41 to 50 of about 11,146 (287)

Coma and vegetative states: state of the art and proposal of a novel approach combining existing coma scales

Annali dell'Istituto Superiore di Sanità, 2014
Brain damage of various aetiologies can lead to different disorders of consciousness (DOC), varying from coma to vegetative, to minimally conscious states.
Luca Tommaso Bonsignore, Simone Macrì, Paolo Orsi, Flavia Chiarotti, Enrico Alleva   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

Detecting fluctuation of responsiveness in Minimally Conscious State patients [PDF]

, 2023
Minimally Conscious State (MCS) is a disorder of Consciousness (DOC) showing a within/between subject (spontaneous) variability of clinical signs of responsiveness. Such fluctuations in responsiveness could prevent patients to access the Brain Computer
Gianluca Di Flumeri, Pietro Aricò, Rita Formisano, Valentina Caracci, Valentina Galiotta, Jlenia Toppi, Febo Cincotti, Mariagrazia D’Ippolito, Angela Riccio, Donatella Mattia, Ilaria Quattrociocchi   +10 more
core  

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

EEG indices of responsiveness in Minimally Conscious State [PDF]

, 2023
Minimally Conscious State (MCS) is a clinical condition characterized by reproducible, but inconsistent signs of consciousness. Fluctuations of responsiveness contribute to the misdiagnosis rate and prevent from effective interactions with MCS patients ...
Pietro Aricò, Rita Formisano, Valentina Caracci, Valentina Galiotta, Jlenia Toppi, Febo Cincotti, Mariagrazia D’Ippolito, Donatella Mattia, Angela Riccio, Ilaria Quattrociocchi   +9 more
core  

Children in Vegetative State and Minimally Conscious State: Patients’ Condition and Caregivers’ Burden

The Scientific World Journal, 2012
Caring for children in vegetative state (VS) or minimally conscious state (MCS) challenges parents and impacts on their well-being. This study aims to evaluate caregivers’ health condition, coping, anxiety and depression levels, and how these issues ...
A. M. Giovannetti, M. Pagani, D. Sattin, V. Covelli, A. Raggi, S. Strazzer, E. Castelli, A. Trabacca, A. Martinuzzi, M. Leonardi   +9 more
doaj   +1 more source

Functional connectivity substrates for tDCS response in Minimally Conscious State patients

Frontiers in Cellular Neuroscience, 2016
Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients ...
Carlo Cavaliere, Carlo Cavaliere, Marco Aiello, Carol Di Perri, Enrico Amico, Charlotte Martial, Aurore Thibaut, Steven Laureys, Andrea Soddu   +8 more
doaj   +1 more source

Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier, Ugo Sorrentino, Matias Wagner, Marta Zawadzka, Anna Lemska, Maria Mazurkiewicz‐Bełdzińska, Michael Zech   +6 more
wiley   +1 more source

Sleep Homeostasis in the Vegetative and Minimally Conscious States [PDF]

, 2010
The EEG slow-wave activity (SWA) organization in temporal cycles with an exponential trend of attenuation over the wakefulness-sleep cycle is thought to reflect synaptic homeostasis.
S. Garbarino, A. Bricolo, P. Lanteri, A. Corica, C. Bianconi   +4 more
core   +1 more source