Results 21 to 30 of about 234 (89)
Abstract Follicular lymphoma (FL) is the most common indolent lymphoma. Although chemoimmunotherapy is effective, toxicity remains problematic, and novel treatments are required. We performed a Phase Ib/II study of obinutuzumab, lenalidomide, and venetoclax in patients with treatment‐naïve, high tumor burden, advanced‐stage FL. During induction (6 × 28‐
Chan Y. Cheah +11 more
wiley +1 more source
ABSTRACT Depicting patient transitions among multiple clinical states is a common objective in health services and epidemiological research. Multistate models (MSM) are the primary analytical approach used in such studies. Although the structure of an MSM is typically determined by the research questions of a specific application, models are typically ...
Jason Mao, Yang Li, Wanzhu Tu
wiley +1 more source
Subgroup Identification via Multiple Change Point Detection: Methods and Applications
Subgroup identification methods facilitate the discovery of clinically meaningful subpopulations with differing disease progression, improving personalized risk assessment and treatment strategies. ABSTRACT Subgroup identification is a significant research area in statistics and machine learning, aiming to partition a heterogeneous population into more
Yaguang Li +3 more
wiley +1 more source
Covariance Estimation for Wide Data
Covariance matrix estimation is fundamental to multivariate analysis, with applications spanning finance, genomics, climate science, and signal processing. This review synthesizes recent advances in high‐dimensional covariance estimation‐thresholding, linear and nonlinear shrinkage, graphical models, and random matrix theory‐under a unifying framework ...
Eran Raviv
wiley +1 more source
Transient Porosity During Fluid‐Mineral Interaction, Part 2: Reconstruction Using Generative AI
Abstract Quantifying fluid–rock interactions within the lithosphere is vital for both geological processes and applications such as CO2 ${\text{CO}}_{2}$ storage and geothermal energy development. Mineral replacement reactions generate transient pore networks that enhance fluid flow, yet many pores become isolated once reactions are completed, reducing
Hamed Amiri +5 more
wiley +1 more source
Abstract Atmosphere‐ocean‐land coupled forecasting systems, despite their comprehensiveness, face substantial challenges in the “predictability desert” at subseasonal to seasonal (S2S) timescales, particularly for precipitation—a variable crucial for socioeconomic activities yet of stunning spatiotemporal variance. Post‐processing methods developed for
Wen Shi +9 more
wiley +1 more source
Bayesian Decision Thresholds for Bushfire Warnings: Calibration and Robustness for Rare‐Event Risk
ABSTRACT Current bushfire warning systems communicate the probability of a warning given danger, but residents require the probability of danger given a warning. This misalignment, combined with the extreme rarity of catastrophic fires, often leads to the dangerous ‘wait and see’ behaviour.
Miodrag Lovric, Ojas Davé
wiley +1 more source
Objective Immunothrombosis contributes to ischemic stroke pathophysiology through neutrophil extracellular trap (NET) formation, which promotes thrombus stabilization and microvascular dysfunction. DNase1 is the principal endonuclease responsible for NET degradation.
B. Díaz‐Benito +10 more
wiley +1 more source
Agentic Finance: An Adaptive Inference Framework for Bounded-Rational Investing Agents. [PDF]
Montañez Jacquez S +2 more
europepmc +1 more source

