Results 41 to 50 of about 213,568 (263)
The Minimum Universal Cost Flow in an Infeasible Flow Network [PDF]
Journal of Sciences, Islamic Republic of Iran, 2006 In this paper the concept of the Minimum Universal Cost Flow (MUCF) for an infeasible flow network is introduced. A new mathematical model in which the objective function includes the total costs of changing arc capacities and sending flow is built and ...
doaj
On the complexity and approximability of budget-constrained minimum cost flows [PDF]
Information Processing Letters, 2017 We investigate the complexity and approximability of the budget-constrained minimum cost flow problem, which is an extension of the traditional minimum cost flow problem by a second kind of costs associated with each edge, whose total value in a feasible flow is constrained by a given budget B.
Michael Holzhauser +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Flow Increment through Network Expansion
Mathematics, 2021 The network expansion problem is a very important practical optimization problem when there is a need to increment the flow through an existing network of transportation, electricity, water, gas, etc.
Adrian Marius Deaconu, Luciana Majercsik
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Energies, 2021 The circulating cooling water system is widely used in various industrial production fields, and its operating cost largely depends on external factors, such as ambient temperature and working medium flow.
Peng Wang +4 more
doaj +1 more source
Multiple objective minimum cost flow problems: A review [PDF]
European Journal of Operational Research, 2007 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hamacher, Horst W. +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source