Results 101 to 110 of about 6,008 (306)
Mobile messenger RNAs (mRNAs) can travel long distances, serving as systemic signals that participate in plant growth and stress acclimation. This work determines that PHR proteins mediate the Pi starvation response (PSR)‐specific long‐distance transport of mRNAs and that these PSR‐specific mobile mRNAs represent noncoding transcripts in recipient ...
Weiguo Dong +9 more
wiley +1 more source
Minimum variance quadratic unbiased estimation of variance components
AbstractThe variance of a quadratic function of the random variables in a linear model is minimized to obtain locally best unbiased estimators (MIVQUE) of variance components. Condition for such estimators to be independent of the kurtosis of the variables is given.
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This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen +31 more
wiley +1 more source
Uniform minimum variance unbiased estimators for bivariate families
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong +21 more
wiley +1 more source
Mechanical Cues Regulate Cargo Sorting and Export at the Golgi
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino +21 more
wiley +1 more source
Considering that the choice of loss function plays a significant role in the derivation of Bayesian estimators, we propose a novel asymmetric loss function named the weighted Q-symmetric entropy loss for computing the estimates of the parameter and ...
Kexin He, Wenhao Gui
doaj +1 more source
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance +17 more
wiley +1 more source
Minimum variance unbiased estimation of the parameters of the Pareto distribution
This paper presents a simpler proof of some results concerning estimation of the Pareto distribution due toLikes [1969].
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