Results 31 to 40 of about 6,072 (305)
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Some puzzles appearing in statistical inference
Comptes Rendus. MathématiqueRao-Blackwell theorem is widely known to be a mathematically powerful technique that can be used to improve the precision of an estimator. The procedure entails exploiting a sufficient statistic to obtain an improved estimator or a uniformly minimum ...
Alemam, Seyf +2 more
doaj +1 more source
On evaluating the efficiency of the delta-lognormal mean estimator and predictor
MethodsX, 2022 A variable taking positive values from a lognormal distribution and null values with a given probability is distributed according to the so-called delta-lognormal distribution.
Philippe Aubry
doaj +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Asymptotic Efficiency of Minimum Variance Unbiased Estimators
The Annals of Statistics, 1977 Consider a regular $p$-dimensional exponential family such that either the distributions are concentrated on a lattice or they have a component whose $k$-fold convolution has a bounded density with respect to Lebesgue measure. Then, if a parametric function has an unbiased estimator, the minimum variance unbiased estimators are asymptotically ...
openaire +2 more sources
Traumatic Microhemorrhages Are Not Synonymous With Axonal Injury
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Diffuse axonal injury (DAI) is caused by acceleration‐deceleration forces during trauma that shear white matter tracts. Susceptibility‐weighted MRI (SWI) identifies microbleeds that are considered the radiologic hallmark of DAI and are used in clinical prognostication.
Karinn Sytsma +9 more
wiley +1 more source
Estimation a Stress-Strength Model for P(Yr:n_1< Xk:n_2) Using the Lindley Distribution
Revista Colombiana de Estadística, 2017 The problem of estimation reliability in a multicomponent stress-strength model, when the system consists of k components have strength each component experiencing a random stress, is considered in this paper. The reliability of such a system is obtained
MARWA KH HASSAN
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel +8 more
wiley +1 more source
An unbiased minimum variance non-parametric analytic and likelihood estimator for discrete and continuous score spaces [PDF]
, 2021 Landon Hurley
openalex +1 more source
Arthritis Care &Research, EarlyView.Objective The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyrophosphate (CPP) crystal arthritis. Methods We conducted a post hoc analysis of the COLCHICORT trial, which compared colchicine and prednisone for the treatment of acute CPP crystal arthritis, using a ...
Tristan Pascart +14 more
wiley +1 more source