Results 31 to 40 of about 6,008 (306)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Some puzzles appearing in statistical inference

Comptes Rendus. Mathématique
Rao-Blackwell theorem is widely known to be a mathematically powerful technique that can be used to improve the precision of an estimator. The procedure entails exploiting a sufficient statistic to obtain an improved estimator or a uniformly minimum ...
Alemam, Seyf, Homei, Hazhir, Nadarajah, Saralees   +2 more
doaj   +1 more source

Establishment of Preliminary Test Estimators and Preliminary Test Confidence Intervals for Measures of Reliability of an Exponentiated Distribution Based on Type-II Censoring

Statistica, 2019
The present paper has developed the preliminary test estimators (PTEs) of the model parameter raised to certain power, σp, and the two measures of reliability, namely, the reliability function, R(t ) and the reliability of an item or a system, P of an ...
Ajit Chaturvedi, Anshika Bhatnagar
doaj   +1 more source

On evaluating the efficiency of the delta-lognormal mean estimator and predictor

MethodsX, 2022
A variable taking positive values from a lognormal distribution and null values with a given probability is distributed according to the so-called delta-lognormal distribution.
Philippe Aubry
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Estimation a Stress-Strength Model for P(Yr:n_1< Xk:n_2) Using the Lindley Distribution

Revista Colombiana de Estadística, 2017
The problem of estimation reliability in a multicomponent stress-strength model, when the system consists of k components have strength each component experiencing a random stress, is considered in this paper. The reliability of such a system is obtained
MARWA KH HASSAN
doaj   +1 more source

Asymptotic Efficiency of Minimum Variance Unbiased Estimators

The Annals of Statistics, 1977
Consider a regular $p$-dimensional exponential family such that either the distributions are concentrated on a lattice or they have a component whose $k$-fold convolution has a bounded density with respect to Lebesgue measure. Then, if a parametric function has an unbiased estimator, the minimum variance unbiased estimators are asymptotically ...
openaire   +2 more sources

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source