Results 161 to 170 of about 16,408 (292)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Catalogue of small runs nonregular designs from Hadamard matrices with generalized minimum aberration

open access: yes, 2000
Fries and Hunter (1980) proposed the Minimum Aberration Criterion (MA) for selecting regular designs. The regular designs with MA are most commonly used because they are considered as the best designs.
Deng, Lih Yuan, Tang, Boxin, Li, Yingfu
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Some results on generalized minimum aberration for symmetrical fractional factorial designs

open access: yes
Generalized minimum aberration of fractional factorial designs has popularly been discussed. Recently, Lu et al. (Technical Report-324, 2002) proposed a so-called nearest balance criterion, which extends the V-criterion studied by Tang (Biometrika, 88 ...
Qin, Hong, Chen, Yin-Bao
core  

Practical inference from industrial split-plot designs. [PDF]

open access: yes
Many industrial response surface experiments are deliberately not conducted in a completely randomized fashion. This is because some of the factors investigated in the experiment are hard to change.
Goos, Peter   +2 more
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

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