Results 251 to 260 of about 477,458 (300)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Multiscale parcellation of dynamic causal models of the brain. [PDF]

Imaging Neurosci (Camb)
Zarghami TS.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Elevated MyoD1 levels expand genome-wide binding and the repertoire of regulated genes. [PDF]

Proc Natl Acad Sci U S A
Whitney ON, Dailey GM, McKenna JK, Darzacq X, Tjian R.   +4 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Epithelial thickness gradients as a diagnostic biomarker for early-stage keratoconus. [PDF]

Int Ophthalmol
Jansone-Langina Z, Gertnere J, Kezika V, Rocha-de-Lossada C, Sánchez-González JM.   +4 more
europepmc   +1 more source

Beyond biometry: the role of fetal venous doppler in discriminating fetal growth restriction from small for gestational age and predicting adverse perinatal outcomes. [PDF]

BMC Pregnancy Childbirth
Filiz AA, Karabay G, Çakir BT, Kından A, Aktemur G, Şeyhanlı Z, Lekesiz B, Sümer D, Dağdeviren G.   +8 more
europepmc   +1 more source

Redesigning EWOD Interconnections: Inkjet-Printed PEDOT:PSS Electrodes with Enhanced Pad Access. [PDF]

ACS Omega
Abdul Latip EN, Coudron L, Munro I, Chung E, Weerasiri L, Johnston I, Tan C.   +6 more
europepmc   +1 more source

Sit-to-Stand Navicular Drop Test-Based Injury Risk Zones Derived from a U-Shaped Relationship in Male University Athletes. [PDF]

J Clin Med
Domaradzki J.
europepmc   +1 more source