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Measuring Minimum Inhibitory Concentrations in Mycobacteria
2009An agar dilution method for measuring minimum inhibitory concentrations (MICs) of Mycobacterium tuberculosis, based on the method of proportion, is described. Mycobacterium strains are grown on Middlebrook 7H10 (or 7H11) agar medium with twofold serially diluted drug concentrations in order to determine specific inhibitory values.
Frederick A. Sirgel +2 more
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The Lancet, 2001
For a drug to be clinically useful, plasma concentrations of the agent must achieve effective concentrations. Logically, therefore, optimum administration of drugs includes selection of doses that provide adequate exposure. This approach has been successfully used during drug development—eg, for antibacterials 1 —and has been applied to agents used in ...
Edward P. Acosta +2 more
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For a drug to be clinically useful, plasma concentrations of the agent must achieve effective concentrations. Logically, therefore, optimum administration of drugs includes selection of doses that provide adequate exposure. This approach has been successfully used during drug development—eg, for antibacterials 1 —and has been applied to agents used in ...
Edward P. Acosta +2 more
openaire +3 more sources
Determining Minimum Inhibitory Concentrations in Liquid Cultures or on Solid Medium
2021Antimicrobial susceptibility testing is the mainstay of tuberculosis drug development programs. In this chapter, we describe methods for determination of the minimum inhibitory concentration of compounds against Mycobacterium tuberculosis growing in liquid media as a function of carbon source, detergent, and environmental stress imposed by acidic pH as
Helena I. Boshoff, Qinglan Wang
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Clinical relevance of Minimum Inhibitory Concentrations (MICs)
Aquaculture, 2001This paper considers the practical approach taken to choosing the best antibiotic treatment for a bacterial disease. Comparisons are made between minimum inhibitory concentration (MIC) and Disc Diffusion methods of determining antibiotic sensitivity of pathogenic bacteria in practice.
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Correlation of minimum inhibitory concentration and beta-lactamase activity
Infection, 1977The beta-lactamase activity of 510 recently isolated Enterobacteriaceae was investigated with a quantitative photometric test. Beta-lactamase could be detected in 55 percent of the Enterobacteriaceae. At the same time minimal inhibition concentration (MIC) of beta-lactam antibiotics was determined.
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2012 IEEE Sensors, 2012
Antibiotics are useful for treatments of a wide variety of infections. However, their performance has not been fully exploited because of a lack of approaches to rapidly select appropriate antibiotics and their concentrations. In this study, we propose a microsystem that can be used for rapid and on-site selection of antibiotics.
Nobuhiko Nomura +4 more
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Antibiotics are useful for treatments of a wide variety of infections. However, their performance has not been fully exploited because of a lack of approaches to rapidly select appropriate antibiotics and their concentrations. In this study, we propose a microsystem that can be used for rapid and on-site selection of antibiotics.
Nobuhiko Nomura +4 more
openaire +2 more sources
Toxicological & Environmental Chemistry, 2019
Numerous studies have been reported on today’s ubiquitous presence of antibiotics in surface waters causing the emergence of multidrug-resistant bacteria.
M. Voigt +3 more
semanticscholar +1 more source
Numerous studies have been reported on today’s ubiquitous presence of antibiotics in surface waters causing the emergence of multidrug-resistant bacteria.
M. Voigt +3 more
semanticscholar +1 more source
minimum inhibitory concentration (MIC)
2009lowest concentration of an antibacterial agent that inhibits visible growth of a specific microorganism; → see also antiseptic.
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Computerized Interpretation of Minimum Inhibitory Concentration Antimicrobic Susceptibility Testing
American Journal of Clinical Pathology, 1981Quantitative antimicrobic susceptibility tests by determining the minimum inhibitory concentration (MIC) are becoming more and more prevalent in United States laboratories. Interpretation of MIC values is complex and should be considered as part of the laboratory service.
Richard K. Wertz, John E. Swartzberg
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Comparison of Minimum Inhibitory Concentration (MIC) value of statin drugs: A Systematic Review
Anti-Infective Agents, 2018Microbial infection and its resistance to clinically approved drugs create a huge threat to human health. Emerging reports have indicated the potential of statin drugs in the treatment of various types of microbial infections.
Meenakshi Gupta and Anoop Kumar
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