Results 21 to 30 of about 40,437 (189)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Minimum BER Criterion and Adaptive Moment Estimation Based Enhanced ICA for Wireless Communications

IEEE Access, 2020
This paper concentrates on investigating an enhanced independent component analysis (ICA) method for blind separation of signals corrupted by noise in wireless communications.
Zhongqiang Luo, Yan Chen, Chengjie Li, Xingzhong Xiong, Lidong Zhu   +4 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Pulsar Radio Emission Altitude from Curvature Radiation

, 2004
We assume that the relativistic sources moving along the dipolar magnetic field lines emit curvature radiation. The beamed emission occurs in the direction of tangents to the field lines, and to receive it, the sight line must align with the tangent ...
Biggs J. D., Gil J. A., Kramer M., Lyne A. G., Mitra D., Narayan R., R. T. Gangadhara, Radhakrishnan V.   +7 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Four-dimensional dynamic flow measurement by holographic particle image velocimetry [PDF]

, 2005
The ultimate goal of holographic particle image velocimetry (HPIV) is to provide space- and time-resolved measurement of complex flows. Recent new understanding of holographic imaging of small particles, pertaining to intrinsic aberration and noise in ...
Meng, Hui, Pu, Ye
core   +2 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Invariance of generalized wordlength patterns

, 2008
The generalized wordlength pattern (GWLP) introduced by Xu and Wu (2001) for an arbitrary fractional factorial design allows one to extend the use of the minimum aberration criterion to such designs. Ai and Zhang (2004) defined the $J$-characteristics of
Beder, Jay H., Willenbring, Jeb F.
core   +2 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Column ratio mapping: a processing technique for atomic resolution high angle annular dark field(HAADF) images [PDF]

, 2008
An image processing technique is presented for atomic resolution high-angle annular dark-field (HAADF) images that have been acquired using scanning transmission electron microscopy (STEM).
Alan J. Craven, Batson, Boothroyd, Boothroyd, Cheng, Cowley, Davies, Dellby, Dwyer, Egerton, Galindo, Haider, Hillyard, Hillyard, Ikarashi, Ikarashi, Kim, Kirkland, Klenov, Klenov, Krivanek, Krivanek, Larkner, Loane, Nag, Nellist, Neumann, Paul D. Robb, Pennycook, Pennycook, Pennycook, Plamann, Rafferty, Scott, Stradling, Treacy, Valera   +36 more
core   +1 more source