Results 111 to 120 of about 2,902,197 (338)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Advanced technology for minimum weight pressure vessel system [PDF]

open access: yes
Bosses were made of fiber/resin composite materials to evaluate their potential in lightweight pressure vessels. An approximate 25% weight savings over the standard aluminum boss was achieved without boss failures during burst tests.
Hamstad, M. A.   +2 more
core   +1 more source

Optimum matchings in weighted bipartite graphs [PDF]

open access: yes, 2014
Given an integer weighted bipartite graph $\{G=(U\sqcup V, E), w:E\rightarrow \mathbb{Z}\}$ we consider the problems of finding all the edges that occur in some minimum weight matching of maximum cardinality and enumerating all the minimum weight perfect
C. Vargas, Carlos E. Valencia, Marcos
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Optimal sorting of product into fixed weight packaging [PDF]

open access: yes, 2004
Compac Sorting Equipment make very nifty machines for sorting fruit by weight, diameter, colour, density, blemish or even shape. Compac sought solutions to two closely related problems: the boxing problem and the bagging problem.
Kilby, Philip, Marsh, Clive
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Design and fabrication of a boron reinforced intertank skirt [PDF]

open access: yes
Analytical and experimental studies were performed to evaluate the structural efficiency of a boron reinforced shell, where the medium of reinforcement consists of hollow aluminum extrusions infiltrated with boron epoxy.
Henshaw, J., Pylypetz, P., Roy, P. A.
core   +1 more source

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