Results 151 to 160 of about 2,902,197 (338)
Minimum 10 Year Clinical and Radiological Outcomes of a Randomized Controlled Trial Evaluating Accelerated Weight Bearing After Matrix-Induced Autologous Chondrocyte Implantation [PDF]
, 2019 Jay R. Ebert +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Electrical engineering & Electromechanics, 2015 Purpose. To find the analytical expressions of determining the optimum geometric dimensions by criteria of the weight minimum and the cost minimum of axial field squirrel-cage induction motors and to compare traditional and axial field motors ...
А.А. Stavinskii, О.О. Palchykov
doaj
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Weighted minimum $$\alpha$$-Green energy problems
Analysis MathematicaFor the $\alpha$-Green kernel $g^\alpha_D$ on a domain $D\subset\mathbb R^n$, $n\geqslant2$, associated with the $\alpha$-Riesz kernel $|x-y|^{\alpha-n}$, where $\alpha\in(0,n)$ and $\alpha\leqslant2$, and a relatively closed set $F\subset D$, we investigate the problem on minimizing the Gauss functional \[\int g^\alpha_D(x,y)\,d(\mu\otimes\mu)(x,y)-2 ...
openaire +2 more sources
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
The minimum weight of the code of intersecting lines in ${\rm PG}(3,q)$ [PDF]
Sam Adriaensen +2 more
openalex +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Composite Section Design for Minimum Weight in Structural Application
, 2015 Devendra Sonawane +2 more
openalex +1 more source