Results 31 to 40 of about 792,002 (266)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

5-Stars of Low Weight in Normal Plane Maps with Minimum Degree 5

open access: yesDiscussiones Mathematicae Graph Theory, 2014
It is known that there are normal plane maps M5 with minimum degree 5 such that the minimum degree-sum w(S5) of 5-stars at 5-vertices is arbitrarily large.
Borodin Oleg V.   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

An improved performance of greedy heuristic solutions for a bi-criteria mixture packaging problem of two types of items with bounded weights

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2020
In this paper, we treat a lexicographic bi-criteria combinatorial optimization model of mixture packaging of two types of items, which arises in actual food packing systems, so-called multi-head weighers.
Yoshiyuki KARUNO, Oki NAKAHAMA
doaj   +1 more source

On Minimum Maximal Distance-k Matchings [PDF]

open access: yesDiscrete Mathematics & Theoretical Computer Science, 2018
We study the computational complexity of several problems connected with finding a maximal distance-$k$ matching of minimum cardinality or minimum weight in a given graph. We introduce the class of $k$-equimatchable graphs which is an edge analogue of $k$
Yury Kartynnik, Andrew Ryzhikov
doaj   +1 more source

Maximal Flat Antichains of Minimum Weight [PDF]

open access: yesThe Electronic Journal of Combinatorics, 2009
We study maximal families ${\cal A}$ of subsets of $[n]=\{1,2,\dots,n\}$ such that ${\cal A}$ contains only pairs and triples and $A\not\subseteq B$ for all $\{A,B\}\subseteq{\cal A}$, i.e. ${\cal A}$ is an antichain. For any $n$, all such families ${\cal A}$ of minimum size are determined. This is equivalent to finding all graphs $G=(V,E)$ with $|V|=n$
Grüttmüller, Martin   +4 more
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A study on minimum weight design of vertical corrugated bulkheads for chemical tankers

open access: yesInternational Journal of Naval Architecture and Ocean Engineering, 2018
Corrugated bulkhead has been adopted for cargo tank bulkheads of commercial vessels such as bulk carriers, product oil carriers and chemical tankers.
Sang-Hoon Shin, Dae-Eun Ko
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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