Results 81 to 90 of about 2,902,197 (338)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Globally optimal triangulations of minimum weight using Ant Colony Optimization metaheuristic
Journal of Computer Science and Technology, 2010 Globally optimal triangulations are difficult to be found by deterministic methods as, for most type of criteria, no polynomial algorithm is known. In this work, we consider the Minimum Weight Triangulation (MWT) problem of a given set of n points in the
María Gisela Dorzán +3 more
doaj
Polynomial Time Approximation Schemes for the Constrained Minimum Spanning Tree Problem
Journal of Applied Mathematics, 2012 Let G=(V,E) be an undirected graph with a weight function and a cost function on edges. The constrained minimum spanning tree problem is to find a minimum cost spanning tree T in G such that the total weight in T is at most a given bound B. In this paper,
Yen Hung Chen
doaj +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Minor stars in plane graphs with minimum degree five
, 2018 The weight of a subgraph $H$ in $G$ is the sum of the degrees in $G$ of vertices of $H$. The {\em height} of a subgraph $H$ in $G$ is the maximum degree of vertices of $H$ in $G$.
Li, Yangfan, Rao, Mengjiao, Wang, Tao
core +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Minimum switching network for generating the weight of a binary vector [PDF]
, 1973 Vector is divided into three variable sections, and each section is processed by unary-to-binary decoder or adder. Resulting network performs on iterative collection process; all outputs of same kind are collected in same manner.
Anderson, T. O.
core +1 more source