Results 91 to 100 of about 168,749 (297)

Deanthroponymic Names of Ural Minerals: Word-Formation Patterns

open access: yesВопросы ономастики
The study investigates the nomenclature of Ural minerals derived from anthroponyms. The data was sourced from printed and electronic publications on geology and mineralogy. The aim of the research is to analyze the primary word-formation patterns evident
Yuri S. Kostylev   +1 more
doaj   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

open access: yesAdvanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang   +17 more
wiley   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

open access: yesAdvanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang   +16 more
wiley   +1 more source

Adsorption Performance of Modified Diatomite for Heavy Metal Ions in Wastewater

open access: yesKuangchan zonghe liyong
This is an article in the field of mining engineering. The diatomite was modified with sodium dodecyl sulfonate and ferroferric oxide, and the influence of external factors on the adsorption effect was analyzed.
Na QIN, Xinmin LIU
doaj   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

open access: yesAdvanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong   +6 more
wiley   +1 more source

Natural Evaporation Experiment of Sand Gravel Type Pore Brine in Qaidam Basin in Summer

open access: yesKuangchan zonghe liyong
This is an article in the field of mining engineering. The deep sand gravel type pore brine in Qaidam Basin belongs to the unsaturated chloride type brine with high calcium, high sodium and low potassium.
Fang JIN, Jiantuan JIA, Min GUO
doaj   +1 more source

Autopolyploidization‐Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa

open access: yesAdvanced Science, EarlyView.
This study demonstrates that monoploid, diploid, and autotetraploid Brassica rapa lines derived from the same genome exhibit distinct leaf morphology. Ploidy changes remodel chromatin accessibility and histone modifications to regulate gene expression, while key transcription factors BrGRF13 and BrARF11 control leaf size and polarity, driving ...
Haoyuan Dong   +17 more
wiley   +1 more source

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