Results 111 to 120 of about 816,784 (295)

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

open access: yesAdvanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong   +6 more
wiley   +1 more source

Research on Meso-Damage Experiment and Simulation in the Anchorage Bonding Interface Between Rock Bolt and Rock Mass

open access: yesShock and Vibration
Anchorage failure occurs mostly at the anchorage interface, and the mechanical mechanism of the anchorage interface is the key point and difficulty in the analysis and research of anchorage.
Yaxin Liu   +6 more
doaj   +1 more source

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

open access: yesAdvanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li   +9 more
wiley   +1 more source

Mass Spectrometry Imaging‐Assisted Discovery of Gallotannin Biosynthetic Genes in the Root of Paeonia suffruticosa

open access: yesAdvanced Science, EarlyView.
An integrated approach combining mass spectrometry imaging, transcriptomics, and phylogenetic analysis facilitated the efficient identification of genes involved in gallotannin biosynthesis in Paeonia suffruticosa. As a result, a key UGT and several SCPL acyltransferases responsible for biosynthesizing pentagalloylglucose were successfully identified ...
Yushi Liu   +4 more
wiley   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

open access: yesAdvanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang   +16 more
wiley   +1 more source

Paving the Way to Elucidate Hg's Role in Tumorigenesis

open access: yesAdvanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li   +10 more
wiley   +1 more source

Study on the evaluation of workface wall stability based on cloud model

open access: yesScientific Reports
To address the uncertainty and fuzziness during conventional workface rib spalling prediction, a rating system of workface wall stability considering subjective experience factor, mechanical performance of coal mass, workface production condition, and ...
Xichen Zhao   +6 more
doaj   +1 more source

Principle and technology of step strengthening control of soft rock argillization roadway in coal mine

open access: yesMeitan xuebao
The sedimentary rock strata of the coal measure are generally characterised by significant argillity, high water content and weak lithology. The problem of controlling the stability of the surrounding rock in soft rock argillation roadways has become ...
Guichen LI   +6 more
doaj   +1 more source

Female students in engineering Geology, Mining, and Petroleum Engineering Comparison

open access: yesRudarsko-geološko-naftni Zbornik, 1997
Engineering professions generally went last decades through process of feminization, but not equally. The article is focused on one of the most male dominant profession - mining, geology and petroleum engineering (MGPE). This study will examine the percentage of female students and graduates from mining college and their achievement on undergraduate ...
Lažnjak, Jasminka   +1 more
openaire   +4 more sources

Credit Enhancement through Financial Engineering: Freeport-McMoRan's Gold-Denominated Depository Shares [PDF]

open access: yes
In 1993 and early 1994, Freeport McMoRan Copper and Gold (FCX), a mining company, issued two series of gold-denominated depositary shares to raise 430 million dollars expanding their mining capacity in Indonesia.
Chitru S. Fernando   +2 more
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