Results 31 to 40 of about 66,582 (246)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro, María Victoria Zelaya, Hasier Eraña, Javier Sánchez Ruiz de Gordoa, Fermín García‐Amigot, Anika Simonovska‐Serra, María Cristina Caballero, Isidre Ferrer, Ellen Gelpi, Ivonne Jericó, Joaquín Castilla   +10 more
wiley   +1 more source

Mecanismos para prevenir la Corrupción

Civilizar, 2023
Este artículo analiza la gestión realizada por los ministerios en Colombia durante el año 2016 para reducir la  corrupción, mediante la revisión y comparación de las matrices de riesgos de corrupción elaboradas por los 16 ministerios existentes durante ...
Liliana Elizabeth Ruiz, Oscar Mauricio Gomez Miranda   +1 more
doaj  

Difusión y comparabilidad de la información económico-financiera on-line: el caso de Iberoamérica

Revista Facultad de Ciencias Económicas, 2011
El objetivo del siguiente trabajo es generar un ranking a partir de los datos consultados del 2009 de los Ministerios de Economía y Hacienda o en su caso de Finanzas de los países de Iberoamérica más transparentes en divulgar información económico ...
José Antonio Peña Ramos, César Vargas Díaz, Iván Medina Iborra   +2 more
doaj   +1 more source

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas, Mauro Monforte, Angel Sanchez‐Montañez, Penélope Romero‐Duque, Elena Pegoraro, Jordi Díaz‐Manera, Dmitry Vlodavets, Lorenzo Maggi, Marco Moscatelli, Adele D‘Amico, Montse Olivé, Jorge Alonso‐Pérez, Giacomo Comi, José Miguel Escudero‐Fernández, Gabriela S. Urcuyo, Anna Pichiecchio, Angela Berardinelli, Kristl G. Claeys, Claudio Bruno, Chiara Panicucci, Sara Bortolani, Eleonora Torchia, Enzo Ricci, Soledad Monges, Jorge A. Bevilacqua, Jorge Diaz‐Jara, Maggie C. Walter, Simone Thiele, Nicoline Løkken, John Vissing, Susana Quijano‐Roy, Robert Y. Carlier, Nicol C. Voermans, Chiara Marini‐Bettolo, Michela Guglieri, Volker Straub, Lea Leonardis, Francina Munell, David Gómez‐Andrés, Giorgio Tasca   +39 more
wiley   +1 more source

Feeding behavior and follower fishes of Myrichthys ocellatus (Anguilliformes: Ophichthidae) in the western Atlantic

Neotropical Ichthyology
This paper described aspects of feeding behavior of Myrichthys ocellatus in the Western Atlantic, using diving observations and additional data from literature. The feeding behavior of M.
Maria E. Araújo, Pedro H. C. Pereira, João L. L. Feitosa, Guilherme Gondolo, Daniel Pimenta, Mara C. Nottingham   +5 more
doaj   +1 more source

Perspectivas para o marco legal do terceiro setor [PDF]

, 2009
A existência de um ambiente regulatório moderno, claro e estável é fator fundamental para promover a expansão e a qualificação do investimento social privado no Brasil.
Aline Gonçalves de Souza, Eduardo Pannunzio, Elisa Rodrigues Alves Larroudé, Flavia Regina de Souza Oliveira   +3 more
core  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

As entidades sem fins lucrativos e as políticas públicas federais: tipologia e análise de convênios e organizações (2003-2011) [PDF]

, 2013
Realizado pelo Instituto de Pesquisa Econômica Aplicada (IPEA), o estudo apresenta os convênios firmados entre o governo federal e as entidades privadas sem fins lucrativos no Brasil entre 2003 e 2011.
Felix Lopez, Leonardo Barone
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