Results 71 to 80 of about 117,252 (297)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
, 2004 This second situation report is primarily aimed at the Nordic Council, which has long been engaged in work involving the Northern Dimension. The report will also serve as information for the EU Commission and (last, but not least) as a source of ...
core +1 more source
Speed of a political career in the Russian Federation
Вестник университетаThe article examines the features of vertical mobility of federal officials in the modern Russia. As part of the study, the authors analyse the career rate of the executive branch.
O. V. Kryshtanovskaya, V. A. Perepelkin
doaj +1 more source
Nordic Perspectives on Carbon Market Mechanisms
, 2011 The Nordic Council of Ministers appointed, via the Globalization Initiative, the Nordic finance ministers to launch a joint Nordic project regarding the international carbon market.
Nordic Council of Ministers
core +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
The 2007 Dutch Reformed Church Synod Resolution: Impact on gay ministers
HTS Teologiese Studies/Theological Studies, 2015 At the 2007 General Synod of the Dutch Reformed Church (DRC), a compromise resolution was accepted regarding homosexual members. The resolution, inter alia, requires of gay ministers to remain celibate as a prerequisite to be legitimated.
Marietjie van Loggerenberg
doaj +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
Fathers help to improve breastfeeding practice : can Indonesian fathers provide the same help ?
Universa Medicina, 2007 The objectives of this paper are i) to explore factors influencing practices of timely breastfeeding initiation and exclusive breastfeeding with special attention on factors related to the roles of father; and ii) to elaborate possible factors ...
Judhiastuty Februhartanty +2 more
doaj +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source