Results 101 to 110 of about 30,696 (201)

Minocycline inhibits rosacea-like inflammation through the TLR4-mediated NF-κB signaling pathway in vivo and in vitro.

PLoS ONE
BackgroundRosacea is a chronic inflammatory skin disease characterized by multiple intricate pathogenic factors. Previous studies have substantiated the anti-inflammatory properties of minocycline and its potential therapeutic efficacy in treating ...
Piyan Hua, Ying Tu, Zhenghui Yang, Yunting He, Li He, Qiuyan Yao, Hua Gu   +6 more
doaj   +1 more source

Engineered surface strategies to manage dental implant‐related infections

Periodontology 2000, EarlyView.
Abstract When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant‐related infections—one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems.
João Gabriel S. Souza, Bruna E. Nagay, Rodrigo Martins, Martinna Bertolini, Jamil A. Shibli, Conrado Aparicio, Magda Feres, Valentim A. R. Barão   +7 more
wiley   +1 more source

Emerging locally delivered antimicrobial and immunomodulatory approaches for the prevention/treatment of peri‐implant diseases

Periodontology 2000, EarlyView.
Abstract Peri‐implant diseases are dysbiosis‐mediated inflammatory disorders that occur in susceptible hosts. Antimicrobials and immunomodulatory agents therefore might be pertinent as adjunctive measures in the treatment of such disorders. The aim of this narrative review was to examine the existing evidence and assess the effectiveness of emerging ...
Alberto Monje, Ettore Amerio, Irene Mallor, Conrado Aparicio   +3 more
wiley   +1 more source

Long‐term stability of conventional non‐regenerative periodontal treatment for furcation defects

Periodontology 2000, EarlyView.
Abstract Background Furcation involvement (FI) in multi‐rooted teeth poses significant challenges in periodontal therapy due to complex anatomy and difficulty in achieving effective maintenance. FI is associated with increased periodontal destruction, especially in sites with narrow furcation entrances and deep root concavities.
Guo‐Hao Lin, April Martinez, Vincent Li, Eric Lee, Kang‐Wei Tu, Richard Kao, Hom‐Lay Wang   +6 more
wiley   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Treatment of Reactive Histiocytosis With Oclacitinib: A Retrospective Case Series of 10 Dogs

Veterinary Dermatology, EarlyView.
Background: Canine reactive histiocytosis is a proliferative disorder of activated interstitial dendritic cells with cutaneous and systemic forms. An immune‐mediated aetiology is likely, and systemic immunomodulatory agents such as corticosteroids, tetracycline/niacinamide, ciclosporin, azathioprine and leflunomide have been employed for its management.
Christine L. Cain, Andrew Lowe, Elizabeth A. Mauldin   +2 more
wiley   +1 more source

Successful Stepwise Endoscopic Ultrasound‐Guided Cyst Drainage for a Giant Infected Hepatic Cyst: A Case Report

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT A 79‐year‐old man presented with fever and jaundice. Laboratory tests revealed elevated inflammatory markers and hepatobiliary enzymes. Magnetic resonance imaging revealed a 20 × 16 cm giant hepatic cyst compressing the intrahepatic bile ducts.
Kazuki Endo, Haruo Miwa, Shotaro Tsunoda, Akihiro Funaoka, Ritsuko Oishi, Yuichi Suzuki, Yusuke Takeshita, Tomoaki Takahashi, Manabu Morimoto, Shin Maeda   +9 more
wiley   +1 more source

Emergence of Tigecycline‐Resistant Pseudomonas aeruginosa Harbouring tmexC6D6‐toprJ1b From Hospital Sewage in Japan

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
This study isolated a Pseudomonas aeruginosa strain (KAM950) carrying the tmexCD‐toprJ gene cluster from hospital sewage in Japan. The strain exhibited reduced susceptibility to tigecycline and carbapenems, harboured chromosomal tmexC6D6‐toprJ1b and oprD disruption, and belonged to epidemic clone ST244, emphasising emerging multidrug resistance and the
Shotaro Maehana, Masato Suzuki, Naoko Ishimura, Hiroki Izawa, Ryotaro Eda, Masaki Nakamura, Mohan Amarasiri, Takashi Furukawa, Fumiaki Kojima, Kazunari Sei, Makoto Kubo   +10 more
wiley   +1 more source

Imperatorin Mitigates Rosacea‐Like Inflammation by Modulating the Crosstalk Between JNK1 and STAT1

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
IMP treatment disrupts the interaction between JNK1 and STAT1, thereby attenuating STAT1 activity. This interference subsequently diminishes the phosphorylation and nuclear translocation of STAT1, which ultimately results in a reduced production of inflammatory cytokines and chemokines.
Xiaoxue Wang, Zexin Zhu
wiley   +1 more source

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

Advanced Materials Interfaces, Volume 13, Issue 6, 16 March 2026.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton, Chris R. Bowen, Hamideh Khanbareh   +2 more
wiley   +1 more source