This study firstly isolated a tuna‐derived gut probiotic Acinetobacter seifertii YFT067. Dietary administration of YFT067 played significant roles in promoting growth performance, SCFAs production, lipid absorption, and metabolism of the host, indicating YFT067 as a promising probiotic candidate for enhancing tuna aquaculture productivity through ...
Ying Zou +4 more
wiley +1 more source
Harnessing Repurposed Drugs to Enhance Temozolomide Efficacy in Glioblastoma
ABSTRACT Background Glioblastoma (GB) is the most aggressive primary malignant brain tumor in adults and remains associated with poor survival despite surgical resection followed by radiotherapy and temozolomide (TMZ) chemotherapy. Intrinsic and acquired resistance to TMZ, including MGMT‐dependent DNA repair and activation of pro‐survival pathways ...
Ali Nakhaei +5 more
wiley +1 more source
A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel +3 more
wiley +1 more source
SARS‐CoV‐2 Spike Peptides Trigger Nociceptive Responses Through Spinal TLR4 Pathways
ABSTRACT Background Pain is a common neurological manifestation of COVID‐19, yet the mechanisms by which SARS‐CoV‐2 spike protein fragments contribute to nociceptive processing remain poorly understood. We investigated whether spike‐derived peptides directly activate spinal neuroimmune pathways involved in pain signalling.
Bruno Eduardo Silva +15 more
wiley +1 more source
The Impact of Oral‐Gut Microbiota Structure and Its Manipulation on RA Development and Management
(A) Schematic representation of oral–gut microbiota composition in health and rheumatoid arthritis (RA), highlighting the enrichment of beneficial microorganisms (green) under healthy conditions and the expansion of pathogenic microorganisms (orange) in RA‐associated dysbiosis.
Parisa Ahmadi +8 more
wiley +1 more source
A Case of Silicone Allergy Induced by a Subcutaneous Implantable Cardioverter Defibrillator
A 54‐year‐old man developed a granulomatous lesion 7 months after S‐ICD implantation and generator exposure 6 years later. Negative infection workup and positive patch testing supported silicone‐related hypersensitivity. To our knowledge, this is the first reported case of silicone allergy associated with an S‐ICD system.
Wataru Shinkai +9 more
wiley +1 more source
Graphical Abstract of the Experimental Workflow for CRAB Isolate Characterization. ABSTRACT Carbapenem‐resistant Acinetobacter baumannii (CRAB) has been designated a top‐priority critical pathogen by the World Health Organization, and the CDC has also classified it as a serious and immediate public health threat. The Cross‐sectional study was conducted
Hafsa Waseem +5 more
wiley +1 more source
Antimicrobial Resistance of Serratia marcescens Recovered From Aquatic Environments: A Review
Serratia marcescens is a gram‐negative bacillus forming biofilms and showing multidrug resistance. Review (2019–2024) included 13 studies, 90 aquatic isolates. High resistance to β‐lactams, including carbapenems. Genes: blaOXA‐48, blaTEM‐1, aac(6′)‐Ic. Aquatic environments are reservoirs, requiring monitoring and control to prevent spread.
Heloisa Silva Inacio +3 more
wiley +1 more source
Environmental reservoirs in Bangladeshi hospitals harbor phylogenetically diverse, multidrug‐resistant Pseudomonas aeruginosa with extensive biofilm‐forming capacity and class 1 integron‐associated resistance genes. These findings highlight hospital environments as persistent sources of antimicrobial resistance dissemination and underscore the need for
S. M. Kador +9 more
wiley +1 more source
Efficacy and safety of minocycline on patients with acute anterior circulation ischaemic stroke undergoing mechanical thrombectomy (MIST-A): a multicentre, prospective, randomised, open-label, blinded-endpoint, phase 2 trial. [PDF]
Zhang X +20 more
europepmc +1 more source

