Results 71 to 80 of about 40,078 (255)

Minocycline reduces alveolar bone loss and bone damage in Wistar rats with experimental periodontitis.

PLoS ONE
This study aimed to investigate the impact of minocycline on the alveolar bone in experimental periodontitis in rats. Thirty Wistar rats were randomly assigned to three groups: control without periodontitis; experimental periodontitis induced by ligature;
Deborah Ribeiro Frazão, José Mario Matos-Souza, Vinicius Ruan Neves Dos Santos, Rayssa Maite Farias Nazario, Victoria Dos Santos Chemelo, Leonardo Oliveira Bittencourt, Gabriela de Souza Balbinot, Fabrício Mezzomo Collares, Walace Gomes-Leal, Railson Oliveira Ferreira, Cassiano Kuchenbecker Rösing, Alexandru Movila, Rafael Rodrigues Lima   +12 more
doaj   +1 more source

Minocycline modulates NFκB phosphorylation and enhances antimicrobial activity against Staphylococcus aureus in mesenchymal stromal/stem cells

Stem Cell Research & Therapy, 2017
Background Mesenchymal stromal/stem cells (MSCs) have demonstrated pro-healing properties due to their anti-inflammatory, angiogenic, and even antibacterial properties.
Alberto Daniel Guerra, Warren E. Rose, Peiman Hematti, W. John Kao   +3 more
doaj   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Derivation of Mouse Dome‐Shaped Trophoblast Stem Cells With Low Heterogeneity From Blastocysts

Cell Proliferation, EarlyView.
Here, Liu et al. report the generation of mouse dome‐shaped trophoblast stem cells (dTSCs) with low heterogeneity and autonomous differentiation potential. dTSCs robustly generate all trophoblast lineages in vitro and contribute to the placenta in vivo, providing a refined model for studying trophoblast development and related disorders.
Minli Liu, Shaofang Ren, Xinyu Xia, Guanlin Lu, Haojie Yang, Yi Zheng, Jiexiang Zhao, Xiao‐Yang Zhao, Mei Wang   +8 more
wiley   +1 more source

Prurigo Pigmentosa – an increasingly diagnosed dermatological condition associated with ketogenic diet

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
SUMMARY Prurigo pigmentosa (PP) is a rare inflammatory dermatosis, clinically characterized by intensely pruritic, erythematous papules and papulovesicles, with reticular hyperpigmentation upon healing. We herein report four cases in adults of different ethnic backgrounds, in which the disease was associated with ketogenic metabolic states due to ...
Antigona Aliu, Milan Vidakovic, Marcel Krauß, Julia Hyun, Frank Oellig, Thilo Gambichler, Valentina Laura Müller, Alexander Kreuter   +7 more
wiley   +1 more source

The Protective Effect of Minocycline in a Paraquat-Induced Parkinson's Disease Model in Drosophila is Modified in Altered Genetic Backgrounds

Parkinson's Disease, 2012
Epidemiological studies link the herbicide paraquat to increased incidence of Parkinson's disease (PD). We previously reported that Drosophila exposed to paraquat recapitulate PD symptoms, including region-specific degeneration of dopaminergic neurons ...
Arati A. Inamdar, Anathbandhu Chaudhuri, Janis O’Donnell   +2 more
doaj   +1 more source

Protective Effect of Minocycline against Ketamine-induced Injury in Neural Stem Cell: Involvement of PI3K/Akt and Gsk-3 beta Pathway

Frontiers in Molecular Neuroscience, 2016
It has been suggested that ketamine cause injury during developing brain. Minocycline could prevent neuronal cell death through the activation of cell survival signals and the inhibition of apoptotic signals in models of neurodegenerative diseases.
Yang Lu, Shan Lei, Ning Wang, Pan Lu, Weisong Li, Juan Zheng, Praveen Giri, Haixia Lu, Xinlin Chen, Yong Liu, Pengbo Zhang   +10 more
doaj   +1 more source

Revitalization in Traumatized Immature Teeth With External Inflammatory Root Resorption: A Systematic Review

Dental Traumatology, EarlyView.
ABSTRACT Introduction This study aimed to evaluate whether revitalization can be indicated in the treatment of traumatized immature teeth with external inflammatory root resorption (EIRR). Methods The protocol of the review was developed in accordance with the PRISMA checklist and registered in the PROSPERO database (CRD42023446609).
Ghina Al Khourdaji, Timothy Fasham, Samantha Elbhar, Kerstin M. Galler, Tchilalo Boukpessi   +4 more
wiley   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

Profile of minocycline and its potential in the treatment of schizophrenia

, 2014
Lulu Zhang,1,2 Jingping Zhao11Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, 2Department of Psychology, Guangzhou First People’s ...
Zhang L, Zhao J
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