Results 231 to 240 of about 3,876,727 (341)

Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases

Advanced Science, EarlyView.
This study develops RLS‐2, a high‐affinity aptamer that specifically targets injured podocytes, making it a promising candidate for targeted drug delivery. In vitro, RLS‐2 shows stability, specificity, efficient siRNA delivery via AsiCs, and uptake by podocytes.
Chao Zhou, Zhaofeng Luo, Zheng Zhang, Qing Ye, Dongjie Wang, Hanyan Meng, Jiayu Zhang, Shifan Zhu, Lidan Hu, Jianhua Mao   +9 more
wiley   +1 more source

Exploring Perception Types of Humanities Job Seekers in Employment Preparation: Implications for Career Guidance. [PDF]

Behav Sci (Basel)
Jang JH, Lee SY.
europepmc   +1 more source

DPImpute: A Genotype Imputation Framework for Ultra‐Low Coverage Whole‐Genome Sequencing and its Application in Genomic Selection

Advanced Science, EarlyView.
DPImpute is a two‐step pipeline that outperforms existing tools in whole‐genome SNP imputation, particularly under conditions of ultra‐low coverage sequencing, small sample sizes, and limited references. It enables precise imputation for single blastocyst cells, supporting genomic selection at the pre‐implantation stage.
Weigang Zheng, Wenlong Ma, Zhilong Chen, Chao Wang, Tao Sun, Wenjun Dong, Wenjing Zhang, Song Zhang, Zhonglin Tang, Kui Li, Yunxiang Zhao, Yuwen Liu   +11 more
wiley   +1 more source

How to review a manuscript for journal publication: A primer for surgery residents. [PDF]

Surg Open Sci
Zyromski NJ, Stewart D.
europepmc   +1 more source

The Super Enhancer‐Driven Long Noncoding RNA PRKCQ‐AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds

Advanced Science, EarlyView.
PRKCQ‐AS1 is overexpressed due to transcriptional super‐enhancers. PRKCQ‐AS1 RNA forms a complex with MSI2 protein to induce BMX mRNA stabilization and overexpression, ERK protein phosphorylation and neuroblastoma cell proliferation. Compound NSC617570 blocks PRKCQ‐AS1 binding to MSI2, leading to BMX mRNA disassociation from MSI2 protein, BMX reduction,
Sujanna Mondal, Pei Y. Liu, Janith Seneviratne, Antoine De Weck, Pooja Venkat, Chelsea Mayoh, Jing Wu, Jesper Maag, Jingwei Chen, Matthew Wong, Nenad Bartonicek, Poh Khoo, Lei Jin, Louise E. Ludlow, David S. Ziegler, Toby Trahair, Pieter Mestdagh, Belamy B. Cheung, Jinyan Li, Marcel E. Dinger, Ian Street, Xu D. Zhang, Glenn M. Marshall, Tao Liu   +23 more
wiley   +1 more source

Structured follow-up pathway to address unmet needs after transient ischaemic attack and minor stroke (SUPPORT TIA): Feasibility study and process evaluation. [PDF]

PLoS One
Turner GM, Calvert M, Foy R, Atkins L, Collis P, Tearne S, Jowett S, Handley K, Mant J.   +8 more
europepmc   +1 more source

Photosensitivity and Carrier Densities of Perovskite Solar Absorbers

Advanced Science, EarlyView.
A novel analysis of the dark and light I–V curves of perovskite solar cells enables the determination of the charge carrier density, the extraction of the ionicity factor, and the quantification of the gain and loss processes, to name a few. The mechanism causing photosensitivity is attributed to the dissociation/pairing of bipolarons/p‐type large ...
Małgorzata Kot, Katarzyna Gawlińska‐Nęcek, Emilia Pożarowska, Karsten Henkel, Dieter Schmeißer   +4 more
wiley   +1 more source

TH Open-Editor's Highlights of 2024. [PDF]

TH Open
Koenen RR.
europepmc   +1 more source

Medium Spiny Neurons Mediate Timing Perception in Coordination with Prefrontal Neurons in Primates

Advanced Science, EarlyView.
Timing perception is a crucial cognitive function enabling effective navigation in the environment, involving both prospective and retrospective timing. This study investigates the neural mechanisms in monkeys, uncovering distinct processes that shape temporal perception and highlighting the essential role of D2 medium spiny neurons in the striatum as ...
Xinhe Liu, Zhiting Zhang, Lu Gan, Panke Yu, Ji Dai   +4 more
wiley   +1 more source