Results 21 to 30 of about 286,041 (305)

Supporting underrepresented minority women in academic dermatology,

open access: yesInternational Journal of Women's Dermatology, 2020
The lack of underrepresented minorities in medicine (UIM) in dermatology has been well established, but the challenges faced by UIM women in dermatology have not yet been explored. UIM women belong simultaneously to more than one underrepresented group and therefore face complex challenges that are common to women and underrepresented minorities.
openaire   +4 more sources

Grand Design Instrument of Potential Abilities for Placement Test

open access: yesEdukasia: Jurnal Penelitian Pendidikan Islam, 2020
This research aims to develop potential ability instruments for placement tests in graduate degrees. This study used the research and development instrument made by Hambleton and Jones sequences.
Sutrisno Sutrisno, Asih Widi Wisudawati
doaj   +1 more source

The motivation of achievement as a creative impulse of well-being: its relation with the five great factors of personality

open access: yesINFAD, 2016
The purpose of this study was to know the relationship between the Big Five personality dimension and academic achievement motivation. We examined the relationship between the Big Five personality traits and its facets evaluated with the NEO PI-R (Costa
Consuelo Morán Astorga   +1 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Screening of minor psychiatric disorders and burnout among a sample of medical students in St. Petersburg, Russia: a descriptive study

open access: yesMiddle East Current Psychiatry, 2021
Background Despite the general interest of researchers around the world, there are few studies on the psychological wellbeing and burnout among medical students in Russia.
Egor Chumakov   +5 more
doaj   +1 more source

Underrepresented Minorities in Academic Medicine: Is Florida Better Off? [PDF]

open access: yesSouthern Medical Journal, 2014
The state of Florida has experienced challenges recruiting and retaining underrepresented minority faculty in academic medicine, as well as maintaining a population-like balance of minority physicians practicing in the state. We sought to quantify the percentage of practicing minority physicians as compared to the general population of Florida and ...
Kendall M. Campbell   +3 more
openaire   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause   +6 more
wiley   +1 more source

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