Results 81 to 90 of about 1,462,634 (355)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The Impact of Comorbidities among Ethnic Minorities on COVID-19 Severity and Mortality in Canada and the USA: A Scoping Review

Infectious Disease Reports
(1) Current literature on ethnic minorities, comorbidities, and COVID-19 tends to investigate these factors separately, leaving gaps in our understanding about their interactions.
Christina Mac, Kylem Cheung, Tala Alzoubi, Can Atacan, Hibah Sehar, Shefali Liyanage, Bara’ Abdallah AlShurman, Zahid Ahmad Butt   +7 more
doaj   +1 more source

Satisfaction Guaranteed

Journal of College Orientation, Transition, and Retention, 2009
It is widely acknowledged that students' first introduction to college life can have a profound impact on student persistence and educational attainment (Pascarella & Terenzini, 2005).
Adam L. Wade, Diane M. Waryold, Nikki T. Crees   +2 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Library Support for Indigenous University Students: Moving from the Periphery to the Mainstream

Evidence Based Library and Information Practice, 2015
Objective – This research project explored the models of Indigenous support programs in Australian academic libraries, and how they align with the needs of the students they support.
Joanna Hare, Wendy Abbott
doaj   +1 more source

Who Will Be Idol? The Importance of Social Networks for Winning on Reality Shows [PDF]

This paper examines, both theoretically and empirically, the effect of social networks and belonging to minority groups (or race) on the probability of winning in reality television shows.
Heizler (Cohen), Odelia, Kimhi, Ayal
core  

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

The Harold Amos Medical Faculty Development Program: Evaluation of a National Program to Promote Faculty Diversity and Health Equity

Health Equity, 2018
Purpose: The Harold Amos Medical Faculty Development Program (AMFDP), a national program of the Robert Wood Johnson Foundation, seeks to support academic physicians from historically disadvantaged backgrounds and serves as a model program for promoting ...
James P. Guevara, James P. Guevara, Melissa Wright, Nancy W. Fishman, David M. Krol, Jerry Johnson   +5 more
doaj   +1 more source

Structural and functional analysis of Bacillus sarcosine oxidase and its activity toward cyclic imino acids

FEBS Open Bio, EarlyView.
Sarcosine oxidase from Bacillus sp. (SoxB) recognizes l‐proline (l‐Pro), d‐proline (d‐Pro), and l‐thioproline (l‐Tpr) as minor substrates. In this study, we measured their absorption spectra, determined the crystal structures of their enzyme complexes, and performed site‐directed mutagenesis of key residues.
Yuqi Zhang, Yoshitaka Nakajima, Masae Kurobe, Tsutomu Nakamura, Tomoki Himiyama, Yoshiaki Nishiya   +5 more
wiley   +1 more source

Unveiling Compensatory Mechanisms of Muslim Minority Groups in Hungary

Changing Societies & Personalities
The growing population of Muslim consumers and their increasing economic influence have driven the expansion of Islamic goods and services across Europe. However, it is essential to examine how the scarcity of Islamic products and services—or the lack of
Jhanghiz Syahrivar, Tamás Gyulavári, Chairy Chairy   +2 more
doaj   +1 more source