Advanced Science, EarlyView.This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang +11 more
wiley +1 more source
Why the Gap Persists: A Systematic Review of Sociocultural, Clinical, and Systemic Factors Driving Maternal Health Disparities Between Black and White Women in the United Kingdom. [PDF]
CureusAdeyemo SC +6 more
europepmc +1 more source
Efficient Screening of Organic Singlet Fission Molecules Using Graph Neural Networks
Advanced Science, EarlyView.A high‐throughput screening framework based on graph neural networks (GNNs) and multi‐level validation facilitates the identification of singlet fission (SF) candidates. By efficiently predicting excitation energies across 20 million molecules, and integrating TDDFT calculations, synthetic accessibility assessments, and GW+BSE calculations, this ...
Li Fu +5 more
wiley +1 more source
Difficulties in Accessing Mental Health Services: The Perspective of Users from Cultural Minorities. [PDF]
Healthcare (Basel)Iudici A, Gusella G.
europepmc +1 more source
Automated Extraction of Multicomponent Alloy Data Using Large Language Models for Sustainable Design
Advanced Science, EarlyView.A large language model (LLM) based pipeline is developed to automatically extract a comprehensive and accurate multicomponent alloy database from literature corpus. The extracted dataset is integrated with sustainability indicators to identify potential alloys that outperform existing industrial benchmark materials in terms of both performance and ...
Aravindan Kamatchi Sundaram +4 more
wiley +1 more source
Linguistic markers of interpretation bias in nontrauma narratives and associations with PTSD among sexual minority cisgender women, transgender men and women, and gender diverse people. [PDF]
Psychol TraumaChasten NT +8 more
europepmc +1 more source
Advanced Science, EarlyView.This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li +15 more
wiley +1 more source
From awareness to action: Reimagining cultural responsiveness in pediatric palliative care. [PDF]
Palliat Support CareConsad RR, Valera RS.
europepmc +1 more source
Closing the Empirical Loop: Autonomous AI Agents Conduct End‐to‐end Research With Human Participants
Advanced Science, EarlyView.A multi‐agent AI system autonomously executes the complete scientific workflow, from hypothesis to manuscript, across three psychological studies involving 288 participants. The system designs experiments, collects real world data, develops analysis pipelines, and writes manuscripts with theoretical rigor comparable to experienced researchers.
Gabrielle Wehr +6 more
wiley +1 more source
Advancing maternal health equity: the need for cultural awareness and inclusivity in maternity service delivery in the UK: anchored in the MBRRACE-UK 2025 findings. [PDF]
Int J Equity HealthBolarinwa O.
europepmc +1 more source