Results 181 to 190 of about 983,648 (315)

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

INB3P: A Multi‐Modal and Interpretable Co‐Attention Framework Integrating Property‐Aware Explanations and Memory‐Bank Contrastive Fusion for Blood–Brain Barrier Penetrating Peptide Discovery

Advanced Science, EarlyView.
INB3P is a multimodal framework for blood–brain barrier‐penetrating peptide prediction under extreme data scarcity and class imbalance. By combining physicochemical‐guided augmentation, sequence–structure co‐attention, and imbalance‐aware optimization, it improves predictive performance and interpretability.
Jingwei Lv, Qianyang Wu, Jian Liu, Binlu Yang, Yuanhao Li, Junlin Xu, Yajie Meng, Leyi Wei, Zilong Zhang, Quan Zou, Xiulai Li, Feifei Cui   +11 more
wiley   +1 more source

The Crescent Languages: marginalised minority languages

, 2018
La zone du Croissant linguistique correspond à la frange Nord du Massif Central (Ronjat 1913). Dans cette zone, on pratique traditionnellement des parlers gallo-romans de transition, présentant simultanément des traits typiques des variétés d’oc (occitan limousin, auvergnat) et d’oïl (français, poitevin-saintongeais).
openaire   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Efficient Screening of Organic Singlet Fission Molecules Using Graph Neural Networks

Advanced Science, EarlyView.
A high‐throughput screening framework based on graph neural networks (GNNs) and multi‐level validation facilitates the identification of singlet fission (SF) candidates. By efficiently predicting excitation energies across 20 million molecules, and integrating TDDFT calculations, synthetic accessibility assessments, and GW+BSE calculations, this ...
Li Fu, Longfei Lv, Fan Zhang, Si Zhou, Weiwei Gao, Jijun Zhao   +5 more
wiley   +1 more source

Heterointerface Engineering of Bismuth Nanosheets/Nitrogen‐Doped Carbon Nanoleaves Enables High‑Performance Electrochemical Dechlorination

Advanced Science, EarlyView.
Bismuth nanosheets integrated with nitrogen‐doped carbon nanoleaves are constructed via a 2D‐on‐2D heterointerface engineering strategy. The resulting BiNS/NCL electrode delivers high chloride adsorption capacity, fast kinetics, and stable cyclability. A built‐in electric field at the heterointerface promotes chloride electrosorption and stabilizes the
Bohan Liu, Feifei Pang, Xingtao Xu, Duo Yang, Xi Yu, Sikan Yang, Jiarui Hao, Nithima Khaorapapong, Zhichang Xiao, Xiaoxian Zhao, Yusuke Yamauchi, Shuaihua Zhang   +11 more
wiley   +1 more source

Does Support Meet the Need? A Focus Group Study on Parental Support and Students' Psychological Need Satisfaction in a Minority School Context. [PDF]

Healthcare (Basel)
Vasiou A, Altan S, Vasilaki E, Mavrogianni A, Vleioras G, Anastasakis M, Mastrothanasis K.   +6 more
europepmc   +1 more source

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source

Cultural and linguistic responsiveness in long-term care: A scoping review protocol on programs for residents and staff. [PDF]

PLoS One
Yan W, Montgomery CL, Dennett L, Chamberlain SA.   +3 more
europepmc   +1 more source

In Vivo Electrochemical Monitoring of Safinamide Pharmacokinetics in the Brain Explores Its Correlation With Vision‐Related Neuronal Activity

Advanced Science, EarlyView.
An electrochemical platform based on differential pulse amperometry enables real‐time, selective tracking of safinamide pharmacokinetics in the living brain with high spatiotemporal resolution. When integrated with electrophysiology, this approach reveals that drug‐induced suppression of vision‐related neuronal activity provides mechanistic insight ...
Xiaoke Nan, Chuqi Li, Qianhe Dai, Junlan Zhou, Lijiao Cao, Yuying Liu, Jinger Chen, Meiping Xiong, Yuhang Jiang, Xianchan Li   +9 more
wiley   +1 more source