Results 181 to 190 of about 372,498 (313)

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

open access: yesAdvanced Science, EarlyView.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan   +17 more
wiley   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

open access: yesAdvanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang   +7 more
wiley   +1 more source

Macrophage–Derived Ferritin Exacerbates Silica‐Induced Pulmonary Fibrosis via PIK3R2‐Mediated Fibroblast Differentiation

open access: yesAdvanced Science, EarlyView.
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang   +14 more
wiley   +1 more source

Utilizing Cooperative Proton–Electron Mixed Conduction Induced via Chemical Dedoping of Self‐Doped Poly(3,4‐ethylenedioxythiophene) Nanofilms for In‐Material Physical Reservoirs

open access: yesAdvanced Science, EarlyView.
This study demonstrates a new concept for high‐performance in‐material physical reservoirs (PRs). An intrinsic and cooperative ion–electron state, induced by chemical dedoping in self‐doped poly(3,4‐ethylenedioxythiophene) (S‐PEDOT) nanofilms, enhances the performance of in‐material PRs.
Yuya Ishizaki‐Betchaku   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy