Results 1 to 10 of about 7,334 (206)

The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening

Advanced Science, EarlyView.
A novel method for the preparation of uniform microspheric skin organoids via spinning bioreactors is developed. The organoid consists of a core‐shell structure to mimic the bilayered skin structure with the epidermis on the surface. For efficient drug screening, the organoid is equipped with a luciferase reporter to detect canonical Wnt signaling, and
Jundong Xie, Qingyang Yang, Yanan Zhang, Ke Zheng, Hongya Geng, Yaojiong Wu   +5 more
wiley   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source

Electrochemistry and Antioxidant Activities of Substituted Furanyl Nitrone: The Role of the Nitro Group

ChemElectroChem, EarlyView.
N‐methyl‐nitroaryl‐furanyl‐nitrone (LQB‐569) suffers a 10‐electron reduction, forming a hydrazine group with two terminal hydroxylamine groups. Nitrones’ antioxidant capacity (AO), despite being very low, correlates with their oxidation profiles, and the ones able to oxidize more easily have better results on DPPH• scavenging and ferric‐reducing ...
Danyelle Cândido Santos, Débora de Souza dos Santos Costa, Paulo R. R. Costa, Ayres Guimarães Dias, Messias de Oliveira Silva, Taualia Achira Aly, Vinícius Del Colle, Jadriane Almeida Xavier, Marília O. F. Goulart, Thaissa Lúcio Silva   +9 more
wiley   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Role of Topical Ketoconazole in Therapeutic Hair Care Beyond Seborrhoeic Dermatitis and Dandruff

JEADV Clinical Practice, EarlyView.
ABSTRACT Ketoconazole shampoo has well‐documented consistent efficacy and safety in treating dandruff and seborrhoeic dermatitis (SD) when compared to other active antidandruff ingredients such as selenium sulphide, corticosteroids and zinc pyrithione.
Aditya K. Gupta, Piet De Doncker, Mesbah Talukder   +2 more
wiley   +1 more source

Case Report of a Patient With Psoriasis Vulgaris, Psoriatic Arthritis and Alopecia Universalis Successfully Treated With Tofacitinib and Methotrexate

JEADV Clinical Practice, EarlyView.
We present a case of a 31‐year‐old female with alopecia universalis, psoriasis vulgaris, and psoriatic arthritis, who showed poor response to prior treatments. Following the initiation of a combination therapy with tofacitinib and methotrexate, significant improvements in joint pain and hair regrowth were observed.
Jan Nicolai Wagner, Matthias Augustin, Caroline Gewiss, Carolin Grote, Nesrine Ben‐Anaya   +4 more
wiley   +1 more source

Perceived Stigma Among Adults With Alopecia Areata in the United States

The Journal of Dermatology, EarlyView.
ABSTRACT Alopecia areata (AA) can significantly impact mental/emotional quality of life, which may be partially attributed to disease‐related stigma. We assessed patient‐reported stigma in US adults with AA using data collected from the 2023 US National Health and Wellness Survey.
Genevieve Gauthier, Kent A. Hanson, Helen Tran, Lynne Napatalung, Griffith Bell, Mojgan Sadrarhami, Lulu Lee, Nikoletta Sternbach, Ernest H. Law, Samantha K. Kurosky   +9 more
wiley   +1 more source

Psychosocial and Occupational Burden on Caregivers of Adolescents With Alopecia Areata in Australia

Australasian Journal of Dermatology, EarlyView.
ABSTRACT We conducted a noninterventional, cross‐sectional online survey in Australia from April to July 2023 to investigate the impact of alopecia areata (AA) on psychosocial well‐being, work productivity and quality of life among caregivers of adolescent patients with AA living in Australia.
Rodney Sinclair, Samantha Eisman, Carol M. Y. Lee, Maureen Hitschfeld, Komal Kapoor, Budhaditya Goswami, David Witcombe, Candida da Fonseca Pereira   +7 more
wiley   +1 more source

Advancing antihypertensive drug development

British Journal of Pharmacology, EarlyView.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu, Yanrong Liu, Fozia Zahir Ahmed, Xin Wang, Darren Green, Hongyuan Zhang   +5 more
wiley   +1 more source

The effects of caffeine and adenosine on the microbiome and lipidome of the scalp

International Journal of Cosmetic Science, EarlyView.
At 12 weeks, anti‐hair loss effects were evident with decreased Pseudomonas, Escherichia‐Shigella and Malassezia and increased Talaromyces and Cutibacterium. Lipid levels were impacted, correlating with Escherichia‐Shigella and Talaromyces. Abstract Hair loss is a complex multifactorial process.
Fengzhu Li, Shulin Liu, Zhaoying Han, Yingtian Li, Haowei Chen, Qingying Shi, Jie Tan, Xihong He, Xinyan Liu, Huabing Zhao, Fang Wang   +10 more
wiley   +1 more source