Results 101 to 110 of about 5,832,610 (300)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Deflection Encounters: Motivational Interviewing and Maximal Minutes
Journal of Multidisciplinary Studies in Human Rights and ScienceEN | Abstract: This article is a practice review for the application of Motivational Interviewing (MI) to be applied to First Responder Deflection programming.
Michael D. Clark
doaj +1 more source
VideoGraph: Recognizing Minutes-Long Human Activities in Videos [PDF]
, 2019 Many human activities take minutes to unfold. To represent them, related works opt for statistical pooling, which neglects the temporal structure. Others opt for convolutional methods, as CNN and Non-Local. While successful in learning temporal concepts,
Gavves, Efstratios +2 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
CHORUS Deliverable 4.1: Report of the 1st CHORUS Workshop [PDF]
, 2007 Minutes of Rocquencourt Workshop – INRIA March 13 ...
Karlgren, Jussi
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Comparison of the effect of a Physical Education-Based Stretching Program applied during the Warm-Up, ColdDown and both periods on hamstring extensibility in Primary Schoolchildren. [PDF]
, 2018 Purpose. To compare the effects of a physical education-based stretching program applied during the warm-up, cold-down and both periods on hamstring extensibility in primary schoolchildren. Methods.
Fernández-Rodríguez, Emilio +3 more
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