Results 101 to 110 of about 79,041 (350)

CD3ɛ Nanobody‐Engineered Extracellular Vesicles Driving In Vivo Generation of BiTE‐Secreting CAR‐Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Advanced Science, EarlyView.
HEK‐293T‐derived CD3ε Nb‐engineered EVs to generate dual‐targeting CAR‐T cells directly in vivo. These EVs selectively deliver CAR.BiTE transgenes into T cells and reprogramed to HLA‐G/PD‐L1‐targeting effector cells with enhanced memory and persistence.
Shi‐Wei Huang, Yu‐Chuan Lin, Chih‐Ming Pan, Yeh Chen, Ming‐You Shie, Cheng‐Yu Chen, Kai‐Wen Kan, Yi‐Wen Chen, Ming‐Chao Liu, Chung‐Chun Wu, Yu‐Ting Chiang, Huai‐Ping Ho, Chen‐Yu Lin, Pei‐Ying Lin, Yu‐Han Huang, Steffany Rusli, Wan‐Yu Mao, Pei‐Wen Huang, Sin‐Ting Wang, Wan‐Chen Tsai, Ya‐Hsu Chiu, Ting‐Hsun Lin, Wan‐Ling Chiang, Che‐Kai Chang, Zi‐Lun Lai, Mei‐Chih Chen, Shao‐Chih Chiu, Der‐Yang Cho   +27 more
wiley   +1 more source

Online accompaniment to MIP Relaxations in Factorable Programming

, 2023
Taotao He, Mohit Tawarmalani
openalex   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

What Sets the Radial Locations of Warm Debris Disks?

, 2017
The architectures of debris disks encode the history of planet formation in these systems. Studies of debris disks via their spectral energy distributions (SEDs) have found infrared excesses arising from cold dust, warm dust, or a combination of the two.
Ballering, Nicholas P., Gáspár, András, Rieke, George H., Su, Kate Y. L.   +3 more
core   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

Warm Dust and Spatially Variable PAH Emission in the Dwarf Starburst Galaxy NGC 1705

, 2006
We present Spitzer observations of the dwarf starburst galaxy NGC 1705 obtained as part of SINGS. The galaxy morphology is very different shortward and longward of ~5 microns: short-wavelength imaging shows an underlying red stellar population, with the ...
Aigen Li, Brent A. Buckalew, Bruce T. Draine, Charles W. Engelbracht, Claus Leitherer, Daniel A. Dale, Daniela Calzetti, David J. Hollenbach, de Jong T., Eric J. Murphy, Fabian Walter, George H. Rieke, George Helou, George J. Bendo, Haas M., Helene Roussel, John M. Cannon, John‐David T. Smith, Karl D. Gordon, Kartik Sheth, Lee Armus, Lemke D., Marcia J. Rieke, Martin J. Meyer, Michael W. Regan, Michele D. Thornley, Robert C. Kennicutt, Jr., Stanimirovic S., Thomas H. Jarrett   +28 more
core   +1 more source

Machine Learning Driven Window Blinds Inspired Porous Carbon‐Based Flake for Ultra‐Broadband Electromagnetic Wave Absorption

Advanced Science, EarlyView.
Inspired by the regulation mechanism of window blinds, this study designs an electromagnetic wave‐absorbing metamaterial. By introducing the magneto‐electric coupling concept and integrating it with an artificial intelligence‐based data‐driven collaborative optimization strategy, the material optimizes impedance matching performance and enhances loss ...
Zhe Wang, Wanchong Li, Lu Feng, Zaiqing Yang, Shicheng Jin, Dongxu Zhao, Xiaoyong Wu, Yan Wang, Yu Mao, Jinsong Zhang   +9 more
wiley   +1 more source

Mapping CSC‐Mediated Ovarian Cancer Chemoresistance via CXCR4‐PET to Guide Precision Cisplatin Re‐Sensitization Therapy

Advanced Science, EarlyView.
CXCR4 functions as a potential cancer stem cell‐associated marker linked to chemoresistance in ovarian cancer, and an inhibitor of CXCR4, AMD3100, can enhance the cytotoxic response to cisplatin. Based on these findings, [68Ga]Ga‐Pentixafor positron emission tomography enables selective visualization of CXCR4‐high ovarian cancer, while AMD3100 combined
Lixia Feng, Simei Zhao, Zheng Wei, Wenwen Wang, Feiquan Ying, Lin Huang, Mengna Zhu, Mengqing Chen, Qiang Yang, Si Sun, Dawei Jiang, Lingling Gao, Jing Cai   +12 more
wiley   +1 more source

Co‐Treatment With rhBMP‐2 and Rapamycin Modulates Osteogenesis–Adipogenesis Balance to Enhance Aged Bone Regeneration

Advanced Science, EarlyView.
This study demonstrates that the imbalance between osteogenic and adipogenic differentiation in senescent BMSCs, leading to excessive adipocyte accumulation, which subsequently impairs bone regeneration in aged mice. To address this pathological dysregulation, a novel energy‐supplying hydrogel system (PBR) has been developed to restore balanced ...
Zirui He, Xiaoqiao Bai, Fangru Xie, Xuan Wang, Fan Zhang, Yuanman Yu, Yuan Yuan, Changsheng Liu   +7 more
wiley   +1 more source

The Large Magellanic Cloud: A power spectral analysis of Spitzer images

, 2010
We present a power spectral analysis of Spitzer images of the Large Magellanic Cloud. The power spectra of the FIR emission show two different power laws. At larger scales (kpc) the slope is ~ -1.6, while at smaller ones (tens to few hundreds of parsecs)
A. Li, A. Li, B.E. Westerlund, B.G. Elmegreen, C. Mastropietro, D.A. Green, D.L. Block, J. Crovisier, M. Meixner, P. Dutta, P. Dutta, P. Dutta, P. Dutta, R. Teyssier, R.P. Marel van der, S. Stanimirovic, S. Tonnesen, W.L. Freedman   +17 more
core   +1 more source