Results 41 to 50 of about 15,476 (309)

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Palaeobiodiversity of Knyszyn Forest (NE Poland) Mires Based on the Late Glacial and Holocene Histories of Vascular Plant Species

Diversity, 2023
Peat and lacustrine sediments are a valuable source of knowledge about past biodiversity. Plant macrofossil remains were identified in sediments of mires in northeastern Poland’s Knyszyn Forest. Among them, the remains of species currently absent in this
Danuta Drzymulska
doaj   +1 more source

Famicose peatlands and ungulate hoof diseases: on the meaning of a word from ‘On the meaning of words’ (Festus, 2nd century CE; Paulus Diaconus, 8th century CE) [PDF]

Mires and Peat, 2020
The dictionary ‘On the meaning of words’ was written by the Roman grammarian Marcus Verrius Flaccus (ca. 55 BCE – 20 CE) but has not been preserved. A summary (“epitome”) by Sextus Pompeius Festus (2nd century CE), which did survive in a heavily damaged ...
P. de Klerk, I. Musäus, H. Joosten
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

What, when, who and how? A review of peatland research in Amazonia [PDF]

Mires and Peat
Amazonia is believed to harbour the world’s most extensive tropical peatlands, storing significant amounts of carbon and having high value for biodiversity conservation, climate regulation and human welfare.
Cristina Malpica-Piñeros, Alexandra Barthelmes, Hans Joosten   +2 more
doaj   +1 more source

Ten-year results of a comparison of methods for restoring afforested blanket bog [PDF]

Mires and Peat, 2017
There is growing interest in the restoration of blanket bogs that were afforested during the 1960s to 1980s, to avoid further loss of carbon to the atmosphere and to regain and defragment important blanket bog habitat.
R. Anderson, A. Peace
doaj   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

A synthesis of evidence for the effects of interventions to conserve peatland vegetation: overview and critical discussion [PDF]

Mires and Peat, 2019
Peatlands are valuable but threatened ecosystems. Intervention to tackle direct threats is often necessary, but should be informed by scientific evidence to ensure it is effective and efficient.
N.G. Taylor, P. Grillas, M.S. Fennessy, E. Goodyer, L.L.B. Graham, E. Karofeld, R.A. Lindsay, D.A. Locky, N. Ockendon, A. Rial, S. Ross, R.K. Smith, R. van Diggelen, J. Whinam, W.J. Sutherland   +14 more
doaj   +1 more source