Results 91 to 100 of about 204,529 (383)

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

Advanced Science, EarlyView.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li, Rui Wang, Wenting Luo, Hui Gu, Tianchu Huang, Qiushi Wang, Zhengwei Yuan   +6 more
wiley   +1 more source

Management of diabetes from preconception to the postnatal period: summary of NICE guidance [PDF]

, 2008
Diabetes in pregnancy is associated with risks to the woman (for example, higher rates of miscarriage, preeclampsia, and preterm labour) and to the developing fetus and baby (for example, higher rates of congenital malformations, macrosomia, birth ...
Guideline Development Group, NICE, Mugglestone, M.   +1 more
core   +3 more sources

Thyroid hormone transport and metabolism are disturbed in the placental villi of miscarriage

Reproductive Biology and Endocrinology, 2023
Background It has been long known that thyroid hormone regulates placental villi development, which is associated with the occurrence of miscarriage. However, whether abnormal thyroid hormone metabolism and transport in placental villi are involved in ...
Zhen Yu, Xinghao Feng, Zhongshan Lin, Xuan Li, Shiyue Su, Huiru Cheng, Yuanyuan Yang, Zhaolian Wei   +7 more
doaj   +1 more source

Potential genetic causes of miscarriage in euploid pregnancies: a systematic review.

Human Reproduction Update, 2019
BACKGROUND Approximately 50% of pregnancy losses are caused by chromosomal abnormalities, such as aneuploidy. The remainder has an apparent euploid karyotype, but it is plausible that there are cases of pregnancy loss with other genetic aberrations that ...
Emily Colley, Susan Hamilton, Paul Smith, Neil V. Morgan, A. Coomarasamy, Stephanie Allen   +5 more
semanticscholar   +1 more source

Miscarriage Is Not a Cause of Death: A Response to Berg’s “Abortion and Miscarriage” [PDF]

The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine, 2021
Abstract Some opponents of abortion claim fetuses are persons from the moment of conception. Call these “Personhood-At-Conception” (or PAC), opponents of abortion. Amy Berg (2017, Philosophical Studies 174:1217–26) argues that if fetuses are persons from the moment of conception, then miscarriage kills far more people than abortion. Thus,
openaire   +3 more sources

BLOC1S1 Attenuates B. Melitensis 16M LPS‐Triggered Autophagy by Spatial Confinement of TDP‐43

Advanced Science, EarlyView.
This study explores how B. melitensis 16M LPS and BLOC1S1 regulate autophagy in goat spermatogonial stem cells. The 16M LPS is activating AMPK‐dependent autophagy, increasing LC3B‐II/I ratios and lysosomal genes, while Escherichia coli LPS shows no effect.
Shicheng Wan, Miao Han, Mengfei Zhang, Wenbo Chen, Fangde Xie, Xuan Luo, Wenping Wu, Congliang Wang, Donghui Yang, Bin Han, Haijing Zhu, Haisheng Yu, Na Li, Jinlian Hua   +13 more
wiley   +1 more source

The association between vaginal bacterial composition and miscarriage: a nested case–control study

BJOG: an International Journal of Obstetrics and Gynaecology, 2019
To characterise vaginal bacterial composition in early pregnancy and investigate its relationship with first and second trimester miscarriages.
M. Al-Memar, S. Bobdiwala, H. Fourie, Ramona Manino, Yun S. Lee, Ann Smith, J. Marchesi, D. Timmerman, T. Bourne, P. Bennett, D. MacIntyre   +10 more
semanticscholar   +1 more source

Nociceptive Nerve‐Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140b+ CD146+ Fibroblast Differentiation

Advanced Science, EarlyView.
This study investigates adenomyosis fibrosis in relation to nociceptive nerves. Nociceptive nerve‐secreted CGRP promotes RAMP1hi CD140b+ CD146+ fibroblast differentiation into myofibroblasts through ERK activation, causing severe fibrosis. Rimegepant‐induced CGRP/RAMP1 signaling blockade alleviates fibrosis and restores fertility in a mouse model. This
Zi Ye, Anning Zhao, Xia Li, Yanqing Hao, Dong Huang, Jianmin Chen, Tiantian Li, Yangyang Dai, Wenchao Sun, Lie Ma, Songying Zhang, Liaobing Xin   +11 more
wiley   +1 more source

Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition

Journal of Maternal-Fetal & Neonatal Medicine, 2018
Objective: To evaluate the potential impact of adenomyosis on the pregnancy outcomes by retrospectively investigating adenomyosis-complicated pregnancy cases. Methods: We performed a retrospective case–control study.
A. Hashimoto, Takayuki Iriyama, S. Sayama, Toshio Nakayama, Atsushi Komatsu, Akito Miyauchi, O. Nishii, T. Nagamatsu, Y. Osuga, T. Fujii   +9 more
semanticscholar   +1 more source