Results 131 to 140 of about 97,151 (249)

Phase I Evaluation of Siltartoxatug, a First‐in‐Class Anti‐Tetanus Monoclonal Antibody: Safety, Pharmacokinetics and Pharmacodynamics in Healthy Australian and Chinese Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Siltartoxatug, a first‐in‐class monoclonal antibody targeting tetanus toxin for post‐exposure prophylaxis, was evaluated in two phase I trials in Australian and Chinese healthy adults. In these randomized, double‐blind, placebo‐controlled, dose‐escalation studies, participants received a single intramuscular injection of siltartoxatug (10–250 μg/kg) or
Xinyu Liu, Zhigang Liu, Xiaohu Kuang, Yueming Wang, Xiaoyi Liu, Jiyuan Ding, Xia Zhou, Xin Zhou, Qianyu Liang, Meizhuo Zhang, Hao Zhao, Qingqing Tan, Weihong Zheng, Huaxin Liao, Charlotte Lemech, Wanmei Wang   +15 more
wiley   +1 more source

Recurrent Miscarriage and Associated Factors [PDF]

The incidence of recurrent pregnancy loss in women of reproductive age group is 0.5%–3%, And idiopathic causes accounts for 50%–60% of recurrent pregnancy losses.
Rehana Yasmeen, Rubina Hussain
core   +1 more source

Unintended Pregnancies and Breastfeeding Studies during Central Nervous System Drug Development: How Are they Handled, Is There Room for Improvement?

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnant and breastfeeding individuals are routinely excluded from clinical drug development, creating persistent evidence gaps in pharmacology, safety, and dosing. Despite mandatory contraception and pregnancy testing, unintended pregnancies occur, particularly during the development of central nervous system (CNS) medicines used by women of ...
Sam Schoenmakers, Charlotte Bakker, Alexandra Ganev, Florence Butlen‐Ducuing, Corinne S. de Vries   +4 more
wiley   +1 more source

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

FDG PET/CT imaging and circulating biomarkers of inflammation in desmoplakin cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1485-1489, April 2025.
Abstract Aims Inflammation has been implicated in the pathogenesis of desmoplakin (DSP) cardiomyopathy, and retrospective studies have described abnormal myocardial fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) findings in symptomatic patients eventually diagnosed with DSP cardiomyopathy.
Sanjay Divakaran, Vinay Randhawa, Usman A. Tahir, Matthew Robertson, Anam A. Waheed, Anna Perillo, Leanne Barrett, Ron Blankstein, Mark W. Feinberg, Marcelo F. Di Carli, Neal K. Lakdawala   +10 more
wiley   +1 more source

Threatened Miscarriage: Evidence-Based Status and Advances in Western Medical Treatments. [PDF]

Int J Womens Health
Wang Y, Gao Z, Yao Y, Wu Y, Jiang S, Duan Y, Zhao J, Wu X, Gao J.   +8 more
europepmc   +1 more source

Researching Attitude–Identity Dynamics to Understand Social Conflict and Change

European Journal of Social Psychology, EarlyView.
Abstract Societies undergo constant change, manifested in various ways such as technological developments, economic transitions, reorganization of cultural values and beliefs, or changes in social structures. Individuals play an active role in shaping social and societal change by interactively negotiating its manifestation.
Adrian Lüders, Mike Quayle, Paul Maher, Ana‐Maria Bliuc, Pádraig MacCarron   +4 more
wiley   +1 more source

Everyone Knows It's a Hoax: The Role of Perceived Descriptive Norms in Conspiracy Beliefs

European Journal of Social Psychology, EarlyView.
ABSTRACT People's belief in conspiracy theories is shaped by social influence processes. This contribution investigated these processes in six studies (total N = 2906) by examining the role of descriptive norms, that is, the perception that others endorse conspiracy theories.
Jan‐Willem van Prooijen, Paul K. Bergmann, Vladimira Čavojová, Jakub Šrol   +3 more
wiley   +1 more source

First-Trimester CBC-Derived Inflammatory Indices for Prediction of Miscarriage: A Retrospective Cohort Study. [PDF]

J Clin Lab Anal
Wattanaploy S, Luewan S, Tongsong T.
europepmc   +1 more source

Exploring Cultural and Individual Differences in the Hierarchy of Moral Concern: Evidence From Student Samples Across 41 Cultural Groups

European Journal of Social Psychology, EarlyView.
ABSTRACT Many important historical and contemporary ethical debates (e.g., on slavery, abortion and environmental protection) reflect disagreements about what we owe to different groups of individuals. Recent work in moral psychology has uncovered a seemingly replicable hierarchy of moral concern, but these studies were conducted in a few countries ...
Işıl Ayça Akkuş, Charlie R. Crimston, Kelly Kirkland, Brock Bastian, Bastian Jaeger   +4 more
wiley   +1 more source