Results 171 to 180 of about 74,732 (309)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

open access: yesFEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee   +3 more
wiley   +1 more source

A dimensão social das intervenções técnicas: saúde e cidadania

open access: yesRevista de Terapia Ocupacional da Universidade de São Paulo, 2011
Elisabete Ferreira Mângia
doaj   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

open access: yesFEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama   +7 more
wiley   +1 more source

3D-Printed Devices in Interventional Radiotherapy (Brachytherapy) Applications: A Literature Review. [PDF]

open access: yesJ Pers Med
Rosa E   +11 more
europepmc   +1 more source

Financial Feasibility of Simultaneous Production of Pine Sawlogs, Forage, and Meat Goats on Small Farms in Alabama: A Preliminary Analysis [PDF]

open access: yes
Small and limited resource farmers and landowners in the Alabama Black Belt region face many challenges as they seek to make their farms and forestlands profitable, productive and environmentally sustainable.
Broughton, Brandi, Bukenya, James O.
core   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

open access: yesFEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

Emerging Trends in the Application of Nanosuspension-Based Biomaterials for Anticancer Drug Delivery. [PDF]

open access: yesInt J Nanomedicine
Aldeeb MME   +6 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

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