Results 101 to 110 of about 42,721 (245)

Two Decades of Multimodal Management of Colorectal Liver Metastases With Long‐Term Outcomes

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background The management of patients with colorectal liver metastases (CRLM) is complex and requires a tailored approach based on disease extent, patient age, and comorbidities. Given the heterogeneity in presentation and evolving treatment algorithms, prognostic factors for long‐term survival following liver resection are contested.
Ali Mohtashami, Prajwol Shrestha, Sharon Chen, Jean‐Luc Vrisakis, Nazim Bhimani, Nick Pavlakis, Stephen J. Clarke, Connie I. Diakos, Matthew Wong, Thomas J. Hugh   +9 more
wiley   +1 more source

Mouse models of colorectal cancer. [PDF]

, 2011
Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip, Tong, Yunguang, Yang, Wancai   +2 more
core   +2 more sources

Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient/proficient colon cancer cell lines

International Journal of Hyperthermia, 2015
Hyperthermia is used in combination with conventional anticancer agents to potentiate their cytotoxicity. One of its key events is the synthesis of heat shock proteins (HSPs), which are able to associate with components from DNA repair mechanisms. However, little is known about their relationship with the mismatch repair system (MMR).
Sottile Fleury, Mayra Lis, Losinno, Antonella Denise, Fanelli, Mariel Andrea, Cuello Carrión, Fernando Darío, Montt Guevara, Maria Magdalena, Vargas Roig, Laura Maria, Nadin, Silvina Beatriz   +6 more
openaire   +3 more sources

MAP17 Enhances Chemoresistance and Tumorigenicity of Glioblastoma‐Initiating Cells via the Canonical NF‐кB Pathway

Cancer Science, EarlyView.
MAP 17 is identified as highly expressed in TMZ‐resistant glioblastoma‐initiating cells (GICs). MAP17 enhances GIC proliferation, TMZ resistance, and tumorigenicity through NF‐κB/RELA‐dependent BCL2 upregulation. ABSTRACT Glioblastoma (GBM) is the most common malignant brain tumor in adults.
Shenshen Dou, You Lee Son, Toru Kondo
wiley   +1 more source

Concordance between immunohistochemistry and MSI analysis for detection of MMR/MSI status in colorectal cancer patients

Diagnostic Pathology
Background Recently, screening of colorectal cancer (CRC) patients for mismatch repair/microsatellite instability (MMR/MSI) status is widely practiced due to its potential predictive and prognostic roles and a screening tool to reveal Lynch Syndrome (LS).
Muhammad Ishaque Faizee, NorLelawati A. Talib, Asmah Hanim Bt. Hamdan, Nor Zamzila Bt. Abdullah, Bilal Ahmad Rahimi, Ahmed Maseh Haidary, Ramin Saadaat, Ahmed Nasir Hanifi   +7 more
doaj   +1 more source

Evidence that the DNA mismatch repair system removes 1-nucleotide Okazaki fragment flaps. [PDF]

, 2015
The DNA mismatch repair (MMR) system plays a major role in promoting genome stability and suppressing carcinogenesis. In this work, we investigated whether the MMR system is involved in Okazaki fragment maturation.
Dahal, Basanta K, Kadyrov, Farid A, Kadyrova, Lyudmila Y   +2 more
core   +2 more sources

Non‐Rigid 3D Shape Correspondences: From Foundations to Open Challenges and Opportunities

Computer Graphics Forum, EarlyView.
Abstract Estimating correspondences between deformed shape instances is a long‐standing problem in computer graphics; numerous applications, from texture transfer to statistical modelling, rely on recovering an accurate correspondence map. Many methods have thus been proposed to tackle this challenging problem from varying perspectives, depending on ...
A. Zhuravlev, L. Bastian, D. Cao, N. El Amrani, P. Roetzer, V. Ehm, R. Marin, H. Nishizawa, S. Morishima, C. Theobalt, N. Navab, D. Cremers, F. Bernard, Z. Lähner, V. Golyanik   +14 more
wiley   +1 more source

Complex-based analysis of dysregulated cellular processes in cancer [PDF]

, 2014
Background: Differential expression analysis of (individual) genes is often used to study their roles in diseases. However, diseases such as cancer are a result of the combined effect of multiple genes.
Khanna, Kum Kum, Liu, Chao, Madhamshettiwar, Piyush B., Ragan, Mark A., Simpson, Peter T., Song, Sarah, Srihari, Sriganesh   +6 more
core   +1 more source

Establishing Shape Correspondences: A Survey

Computer Graphics Forum, EarlyView.
Abstract Shape correspondence between surfaces in 3D is a central problem in geometry processing, concerned with establishing meaningful relations between surfaces. While all correspondence problems share this goal, specific formulations can differ significantly: Downstream applications require certain properties that correspondences must satisfy ...
A. Heuschling, H. Meinhold, L. Kobbelt
wiley   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source