Results 111 to 120 of about 42,721 (245)

A rapid, simple DNA mismatch repair substrate construction method

Frontiers in Oncology, 2011
A more flexible and higher yielding in vitro DNA mismatch repair (MMR) substrate construction method, which was developed initially by Wang and Hays, is described for the construction of a nucleotide-based chemical mismatch (G/IU) and a G/T mismatch. Our
Timothy James Kinsella, Timothy James Kinsella, Weinan eDu   +2 more
doaj   +1 more source

Cell-Selective Biological Activity of Rhodium Metalloinsertors Correlates with Subcellular Localization [PDF]

, 2012
Deficiencies in the mismatch repair (MMR) pathway are associated with several types of cancers, as well as resistance to commonly used chemotherapeutics.
Barton, Jacqueline K., Komor, Alexis C., Schneider, Curtis J., Weidmann, Alyson G.   +3 more
core   +2 more sources

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

Targeting MMR-deficient colorectal cancer with a potent small molecule UNI110

Animal Cells and Systems
Mismatch repair (MMR) deficiency is a hallmark of microsatellite instability (MSI) in hereditary non-polyposis colorectal cancer, Lynch syndrome, contributing to resistance against conventional chemotherapy and posing a significant therapeutic challenge.
Enkhzul Amarsanaa, Jung-Min Oh, Seon Young Lee, Saikat Maiti, Sung You Hong, Kyungjae Myung   +5 more
doaj   +1 more source

Metallo-intercalators and metallo-insertors [PDF]

, 2007
Since the elucidation of the structure of double helical DNA, the construction of small molecules that recognize and react at specific DNA sites has been an area of considerable interest.
Barton, Jacqueline K., Pierre, Valerie C., Zeglis, Brian M.   +2 more
core   +1 more source

Effective When Distinctive: The Role of Phonetic Similarity in Nested Dependency Learning Across Preschool Years

Language Learning, EarlyView.
Abstract Parallel tracking of distant relations between speech elements, so‐called nonadjacent dependencies (NADs), is crucial in language development but computationally demanding and acquired only in late preschool years. As processing of single NADs is facilitated when dependent elements are perceptually similar, we investigated how phonetic ...
Dimitra‐Maria Kandia, Angela D. Friederici, Jutta L. Mueller, Claudia Männel   +3 more
wiley   +1 more source

Pathogenic Insights into DNA Mismatch Repair (MMR) Genes-Proteins and Microsatellite Instability: Focus on Adrenocortical Carcinoma and Beyond. [PDF]

Diagnostics (Basel), 2023
Carsote M, Turturea IF, Turturea MR, Valea A, Nistor C, Gheorghisan-Galateanu AA.   +5 more
europepmc   +1 more source

Direct evidence of singlet molecular oxygen [O2 (1Δg)] production from UVA excited 6‐thioguanine

Photochemistry and Photobiology, EarlyView.
6‐Thioguanine (6‐TGua) is incorporated into DNA as a purine analogue, inhibiting cell replication. Patients treated with 6‐TGua are more prone to developing skin cancer due to the photoexcitation of 6‐TGua by UVA radiation (as illustrated in the Jablonski diagram). Upon exposure to UVA, the excited 6‐TGua generates 1O2.
André L. Lopes, Fernanda M. Prado, Helena C. Junqueira, Marisa H. G. Medeiros, Graziella E Ronsein, Jean Cadet, Paolo Di Mascio   +6 more
wiley   +1 more source

Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro

Nature Communications, 2019
Mismatch repair (MMR)-deficient cancers are characterized by microsatellite instability (MSI) and hypermutation. Here authors reveal a mechanism by which replication stress induces MSI and associated induction of mutations in vitro.
Yusuke Matsuno, Yuko Atsumi, Atsuhiro Shimizu, Kotoe Katayama, Haruka Fujimori, Mai Hyodo, Yusuke Minakawa, Yoshimichi Nakatsu, Syuzo Kaneko, Ryuji Hamamoto, Teppei Shimamura, Satoru Miyano, Teruhisa Tsuzuki, Fumio Hanaoka, Ken-ichi Yoshioka   +14 more
doaj   +1 more source

Relationship between Mismatch Repair (MMR) Status and Chemotherapy Response in Colorectal Carcinoma

Majalah Patologi Indonesia
Background Colorectal carcinoma has several pathways that play a role in normal colonic mucosa development into carcinoma, one of microsatellite instability (MSI) pathway. This pathway results from a deficiency in one of the MMR proteins that normally repair genome damage, leading to microsatellite instability high (MSI-H) and excessive mutations. MSI-
Soraya Sagita Desmeradd, Suly Auline Rusminan, Ika Kartika, Erial Bahar   +3 more
openaire   +1 more source