Results 151 to 160 of about 42,721 (245)

Evaluation of Mismatch Repair (MMR) and Breast Cancer-1 (BRCA-1) Statuses in Epithelial Ovarian Cancer

Asian Pacific Journal of Cancer Prevention
This study aims to evaluate the expression of BRCA1 and MMR proteins using immunohistochemistry (IHC) in epithelial ovarian cancers and to explore their clinicopathological correlations.IHC was performed and interpreted for BRCA1, MLH1, MSH2, MSH6, and PMS2.
Richa, Singh, Preeti, Agarwal, Shuchi, Agrawal, Eva, Raman, Vandana, Solanki, Puneet, Prakash, Malti Kumari, Maurya, Riddhi, Jaiswal, Sameer, Gupta   +8 more
openaire   +2 more sources

Outcomes from the English National Lynch Syndrome transformation project

International Journal of Cancer, Volume 158, Issue 9, Page 2369-2379, 1 May 2026.
What's new? The elevated cancer risk conferred by Lynch syndrome can be mitigated through preventive interventions. However, Lynch syndrome often goes underdiagnosed. The National Lynch Syndrome Transformation Project in England aims to ensure that patients newly diagnosed with colorectal or endometrial cancer are offered testing for the syndrome ...
Kevin J. Monahan, Paul Fleming, Neil A. J. Ryan, Laura Monje‐Garcia, Ruth Armstrong, David N. Church, Jackie Cook, Fiona Lalloo, Sally Lane, Frank D. McDermott, Tracie Miles, Corinne Mallinson, Steven A. Hardy, Simone Gelinas, Francesca Faravelli, Frances Elmslie, Adam C. Shaw   +16 more
wiley   +1 more source

The impact of preoperative treatment on mismatch repair protein and HER2 expression in colorectal cancer: an analysis of paired samples

BMC Cancer
Background Colorectal cancer (CRC) is a leading cause of cancer-related mortality, highlighting the necessity for multifaceted treatment strategies, including preoperative treatment (PT), which can enhance surgical outcomes and provide prognostic ...
Zhen Chen, Hui Cao, Jing Zhang, Weixiang Zhong, Xiaodong Teng   +4 more
doaj   +1 more source

PATH-38. ROSETTE-FORMING GLIONEURONAL TUMOR IS DEFINED BY FGFR1 ACTIVATING ALTERATIONS WITH FREQUENT ACCOMPANYING PI3K AND MAPK PATHWAY MUTATIONS [PDF]

, 2019
BACKGROUND Rosette-forming glioneuronal tumor (RGNT) is an uncommon CNS tumor originally described in the fourth ventricle characterized by a low-grade glial neoplasm admixed with a rosette-forming neurocytic component.
Aghi, Manish, Ann Oberheim-Bush, Nancy, Banerjee, Anu, Bannykh, Serguei, Berger, Mitchel, Bollen, Andrew, Born, Donald, Brathwaite, Carole, Buerki, Robin, Butowski, Nicholas, Calixto-Hope, Lucas, Chamyan, Gabriel, Chang, Susan, Clarke, Jennifer, Cooney, Tabitha, Devine, Patrick, Fata, Cynthia, Grafe, Marjorie, Grenert, James, Guo, Hua, Gupta, Nalin, Hervey-Jumper, Shawn, Hofmann, Jeffrey, Jin, Lee-way, Khatib, Ziad, Kleinschmidt-DeMasters, Bette, Kline, Cassie, Lechpammer, Mirna, Lee, Han, Lee, Julieann, Maher, Ossama, McDermott, Mike, Onodera, Courtney, Pekmezci, Melike, Pelaez, Liset, Perry, Arie, Phillips, Joanna, Raffel, Corey, Samuel, David, Scharnhorst, David, Sloan, Emily, Solomon, David, Sun, Peter, Taylor, Jennie, Theodosopoulos, Philip, Tihan, Tarik, Torkildson, Joseph, Van Ziffle, Jessica, Vogel, Hannes, Wood, Matthew   +49 more
core  

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 5, May 2026.
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang, Zengkan Du, Ping Lu, Aimin Jiang, Yadong Guo, Yawei Liu, Zhijing Song, Bing Dai, Wangzheqi Zhang   +8 more
wiley   +1 more source

Tumor‐Associated Fusobacterium nucleatum and Aggressive Architectural Features in Stage II Colorectal Cancer

APMIS, Volume 134, Issue 5, May 2026.
ABSTRACT Tumor budding (TB) and poorly differentiated clusters (PDCs) are histopathological indicators of invasive potential in colorectal cancer (CRC). Concurrently, Fusobacterium nucleatum (F. nucleatum) has emerged as a modulator of CRC progression. The relationship between intratumoral F. nucleatum and aggressive tumor architecture remains unknown.
Mariana Bisarro dos Reis, Monise Tadin Reis, Marcus Matsushita, Gustavo Noriz Berardinelli, Tatiana Camacho Cheregatto, Welinton Hirai, Valiana Teodoro, Denise Peixoto Guimarães, Rui Manuel Reis   +8 more
wiley   +1 more source

Cold atmospheric plasma stabilizes mismatch repair for effective, uniform treatment of diverse colorectal cancer cell types

Scientific Reports
Mismatch Repair (MMR) mechanisms play a pivotal role in rectifying DNA replication errors and maintaining the stability of DNA microsatellite structure.
Yuanyuan He, Fu Lu, Chenmin Jiang, Fanwu Gong, Zhengwei Wu, Kostya Ostrikov   +5 more
doaj   +1 more source

CD8+ T Cell Infiltration Elicits Molecular Subtype‐Biased Clinical Outcomes in Gastric Cancer Patients

Cancer Science, Volume 117, Issue 5, Page 1434-1445, May 2026.
CD8+ T cell infiltration demonstrates distinct clinical significance across molecular subtypes of gastric cancer. High infiltration correlates with improved survival in EBV‐positive and CIN subtypes, while low infiltration predicts better adjuvant chemotherapy response in MSI patients.
Zhen Ling, Jieti Wang, Yun Gu, Ziqiu Zhang, Fei Shao, Chao Lin, Hongyong He, Ruochen Li, Hao Liu, Jiejie Xu   +9 more
wiley   +1 more source

Should immunohistochemical expression of mismatch repair (MMR) proteins and microsatellite instability (MSI) analysis be routinely performed for poorly differentiated colorectal neuroendocrine carcinomas? [PDF]

Endocrinol Diabetes Metab Case Rep, 2020
Luong TV, Nisa Z, Watkins J, Hayes AR.
europepmc   +1 more source