Results 161 to 170 of about 42,721 (245)

Human papilloma virus infection and mismatch repair protein expression in sebaceous neoplasms of the genital area

Histopathology, Volume 88, Issue 6, Page 1221-1228, May 2026.
This study establishes the role of high‐risk HPV infection in cutaneous sebaceous carcinoma of the genital area. An intraepithelial component in a subset of cases poses a challenge to distinguish the entity from squamous cell carcinoma in situ. Rarely, sebaceous neoplasia of the genital area is associated with Muir–Torre syndrome. Aims This study aimed
Katharina Wiedemeyer, Zainab Al‐Shamma, Martin Köbel, Ingrid Ferreira, Paul W. Harms, Thomas Brenn   +5 more
wiley   +1 more source

Distinct genomic subgroups and mutational patterns in undifferentiated/dedifferentiated endometrial carcinoma

BMC Cancer
Background Endometrial cancer represents a significant global health challenge, with undifferentiated and dedifferentiated endometrial carcinoma (UDEC) being a particularly aggressive subset.
Chen-Yang Huang, Angel Chao, Chiao-Yun Lin, Steven G. Rozen, An-Shine Chao, Chen-Bin Chang, Hsiu-Jung Tung, Ren-Chin Wu, Chyong-Huey Lai   +8 more
doaj   +1 more source

Mutation in MSH5 Causes Primary Ovarian Insufficiency and Successful Therapeutic Intervention by In Vitro Fertilisation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Primary ovarian insufficiency (POI) is a genetically heterogeneous disorder characterised by cessation of menstruation before the age of 40 years with elevated levels of follicle‐stimulating hormone. Germline variants in the MSH5 gene cause POI. In this study, we investigated a Han Chinese family with POI.
Bin Mao, Lili Zhang, Xiaodong Zhao, Xiaojuan Xu, Hongfang Liu, Dexiao Song, Peiqiang Li, Santasree Banerjee, Xiaoling Ma, Yongxiu Yang   +9 more
wiley   +1 more source

Surviving without BRCA2: MLH1 gets R-looped in to curtail genomic instability

The Journal of Clinical Investigation
While breast cancer 2 (BRCA2) loss of heterozygosity (LOH) promotes cancer initiation, it can also induce death in nontransformed cells. In contrast, mismatch repair gene mutL homolog 1 (MLH1) is a tumor-suppressor gene that protects cells from cancer ...
Neil Johnson
doaj   +1 more source

No Evidence of Microsatellite Instability in Head and Neck Squamous Cell Carcinoma of Non‐Smokers and Non‐Drinkers

Journal of Oral Pathology &Medicine, Volume 55, Issue 5, Page 611-615, May 2026.
ABSTRACT Introduction While the prevalence of microsatellite instability (MSI) is low in the whole head and neck squamous cell carcinoma (HNSCC) population, it has been suggested to be more prominent in tumors of non‐smokers. Therefore, the goal of this study was to determine the presence of MSI in a cohort of well‐defined HNSCC of non‐smokers and non ...
F. J. Mulder, T. F. B. Gielgens, E. J. de Ruiter, R. de Bree, M. F. C. M. van den Hout, B. Kremer, S. M. Willems, E. J. M. Speel   +7 more
wiley   +1 more source

Population frequency of Predicted pathogenic MisMatch Repair (MMR) gene variants in Lynch syndrome from bioinformatic analyses of the general population. [PDF]

Sci Rep
Guan Y, Huang M, Macrae F, Yin X, Plazzer JP, Savige J.   +5 more
europepmc   +1 more source

Implementing recommendations for routine mismatch repair (MMR) immunohistochemistry (IHC) testing of endometrial cancer and subsequent patient management. [PDF]

BMJ Open Qual
Shawky M, Murrey M, Morrison J.
europepmc   +1 more source

Mismatch Repair (MMR) Gene Mutation Carriers Have Favorable Outcome in Colorectal and Endometrial Cancer: A Prospective Cohort Study. [PDF]

Cancers (Basel)
Yeh JT, Peng HP, Hung FH, Hung CF, Hsieh LL, Yang AS, Wang YA.   +6 more
europepmc   +1 more source

Characterization of mismatch-repair/microsatellite instability-discordant endometrial cancers. [PDF]

Cancer
Riedinger CJ, Esnakula A, Haight PJ, Suarez AA, Chen W, Gillespie J, Villacres A, Chassen A, Cohn DE, Goodfellow PJ, Cosgrove CM.   +10 more
europepmc   +1 more source

Mismatch repair (MMR) status detection is the first step for endometrial cancer patients

Taiwanese Journal of Obstetrics and Gynecology
Peng-Hui, Wang, Szu-Ting, Yang, Wen-Hsun, Chang   +2 more
openaire   +2 more sources