Results 11 to 20 of about 42,721 (245)

Lost opportunities for mismatch repair (MMR) screening among minority women with endometrial cancer. [PDF]

Sci Rep, 2021
AbstractLynch Syndrome (LS) prevalence in underrepresented minorities are lacking. The objective of this study was to assess the prevalence of LS in a minority patient population. Secondary objectives included identifying factors associated with successful LS screening and to characterize clinicopathologic features.
Huang M, Hunter T, Fein LA, Galli J, George S, Schlumbrecht M, McCarter K, Sinno AK, Guido LP, Pinto A.   +9 more
europepmc   +5 more sources

Classification of mismatch repair gene missense variants with PON-MMR [PDF]

Human Mutation, 2012
Numerous mismatch repair (MMR) gene variants have been identified in Lynch syndrome and other cancer patients, but knowledge about their pathogenicity is frequently missing. The diagnosis and treatment of patients would benefit from knowing which variants are disease related.
Heidi, Ali, Ayodeji, Olatubosun, Mauno, Vihinen   +2 more
openaire   +2 more sources

Survey of unaffected BRCA and mismatch repair (MMR) mutation positive individuals [PDF]

Familial Cancer, 2009
Many individuals do not proceed with cancer predisposition testing due to fears of genetic discrimination (GD). We report the results of a survey of 47 unaffected, mutation positive individuals regarding insurance outcomes. Participants recruited from six different Cancer Risk Programs across the country were queried about their experiences with health,
Wendy, McKinnon, Kimberly C, Banks, Joan, Skelly, Wendy, Kohlmann, Robin, Bennett, Kristen, Shannon, Joy, Larson-Haidle, Taka, Ashakaga, Jeffrey N, Weitzel, Marie, Wood   +9 more
openaire   +2 more sources

Explaining the Familial Colorectal Cancer Risk Associated with Mismatch Repair (MMR)-Deficient and MMR-Stable Tumors [PDF]

Clinical Cancer Research, 2007
Abstract Purpose: There is a paucity of data quantifying the familial risk of colorectal cancer associated with mismatch repair (MMR)-deficient and MMR-stable tumors. To address this, we analyzed a population-based series of 1,042 colorectal cancer probands with verified family histories.
Lauri, Aaltonen, Louise, Johns, Heikki, Järvinen, Jukka-Pekka, Mecklin, Richard, Houlston   +4 more
openaire   +2 more sources

Clinicopathological characteristics of high microsatellite instability/mismatch repair-deficient colorectal cancer: A narrative review

Frontiers in Immunology, 2022
Colorectal cancers (CRCs) with high microsatellite instability (MSI-H) and deficient mismatch repair (dMMR) show molecular and clinicopathological characteristics that differ from those of proficient mismatch repair/microsatellite stable CRCs.
Wei-Jian Mei, Mi Mi, Jing Qian, Nan Xiao, Ying Yuan, Ying Yuan, Ying Yuan, Pei-Rong Ding   +7 more
doaj   +1 more source

Mismatch Repair: From Preserving Genome Stability to Enabling Mutation Studies in Real-Time Single Cells

Cells, 2021
Mismatch Repair (MMR) is an important and conserved keeper of the maintenance of genetic information. Miroslav Radman’s contributions to the field of MMR are multiple and tremendous.
Marina Elez
doaj   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

DNA mismatch repair (MMR) genes expression in lung cancer and its correlation with different clinicopathologic parameters. [PDF]

Sci Rep
AbstractLung cancer (LC) is a crucial rapidly developing disease. In Egypt, it is one of the five most frequent cancers. Little is known about the impact of deleted mismatch repair genes and its correlation to clinicopathological characteristics. This study evaluates immunohistochemical expression of the mismatch repair genes (PMS2), (MSH2), (MLH1 ...
Farrag MS, Abdelwahab HW, Abdellateef A, Anber N, Ellayeh MA, Hussein DT, Eldesoky AR, Sheta H.   +7 more
europepmc   +4 more sources

DNA mismatch repair in the context of chromatin

Cell & Bioscience, 2020
DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers characterized by microsatellite instability.
Yaping Huang, Guo-Min Li
doaj   +1 more source

Relationship between the expression of mismatch repair proteins and colorectal cancer with mesenteric tumor deposit

Zhongguo linchuang yanjiu, 2023
Objective To investigate the clinicopathological significance of colorectal cancer with mesenteric tumor deposit(TD) and the relationship with DNA mismatch repair(MMR) protein expression.
HUANG Ke-qiang, TANG Hua, HUANG Qiu-xia, OU Hai-ling
doaj   +1 more source