Results 201 to 210 of about 42,721 (245)

Immune checkpoint inhibitors in children with replication-repair-deficient high-grade gliomas. The South London Paediatric & TYA Neuro-Oncology Network experience

Perez-Somarriba M, Campello A, Benjamin P, Reisz Z, Bodi I, Al-Sarraj S, Bridges LR, Kumar A, Jacques TS, Zebian B, Bleil C, Aquilina K, Hettige S, Mastronuzzi A, Srivatsa K, Cockle J, Mandeville H, Marshall LV, Vaidya S, Stengs L, Bianchi V, Jones C, Lassaletta A, Das A, Tabori U, Carceller F.   +25 more
europepmc   +1 more source

Specificity of the DNA Mismatch Repair System (MMR) and Mutagenesis Bias in Bacteria [PDF]

Molecular Biology and Evolution, 2018
The mutation rate of an organism is influenced by the interaction of evolutionary forces such as natural selection and genetic drift. However, the mutation spectrum (i.e., the frequency distribution of different types of mutations) can be heavily influenced by DNA repair.
Hongan Long, Samuel F Miller, Emily Williams   +2 more
exaly   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

Mismatch repair proteins (MMR) expression as predictive factor in locally advanced rectal cancer.

Journal of Clinical Oncology, 2022
182 Background: Only few data on microsatellite instability in rectal cancer are available in literature, and dMMR role in pre-operative chemoradiotherapy response is under debate. The aim of our study was to evaluate the frequency and therapeutic implications of dMMR status in patients (pts) with locally advanced rectal cancer belonging to our ...
Pretta, A, Donisi, C, Persano, M, Pinna, G, Cimbro, E, Parrino, A, Aimola, V, Spanu, D, Cerrone, G, Deidda, S, Deidda, MA, Lai, E, Pusceddu, V, Puzzoni, M, Ziranu, P, Barbara, R, Restivo, A, Zorcolo, L, Faa, G, Scartozzi, M   +19 more
openaire   +2 more sources

Phenotype associated with recessively inherited mutations in DNA mismatch repair (MMR) genes

Biochemical Society Transactions, 2005
The MMR (DNA mismatch repair) system helps to maintain the integrity of the genome. This involves eliminating base–base mismatches and insertion/deletion loops, which can lead to microsatellite instability, as seen in tumour cells. Hereditary non-polyposis colon cancer is the result of dominant mutations in MMR genes, such as MLH1, MSH2 and MSH6.
M, de Vos, B, Hayward, D T, Bonthron, E, Sheridan   +3 more
openaire   +2 more sources

High frequency mismatch repair (MMR) pathway mutations in adrenocortical carcinoma: Indication for routine MMR-deficiency (MMR-D) testing.

Journal of Clinical Oncology, 2018
e16195Background: Adrenocortical carcinomas (ACC) are rare cancers with overall poor prognosis and limited treatment options.
Omobolaji Oyekunle Akala, Virginia Kelly, Vivian E. Strong, Anuradha Gopalan, Diane Lauren Reidy, Nitya Prabhakar Raj   +5 more
openaire   +1 more source

Analysis of mismatch repair (MMR) proteins expression in a series of malignant pleural mesothelioma (MPM) patients

Clinical and Translational Oncology, 2020
Promising results have been reported with immune checkpoint inhibitors (ICI) in a small proportion of MPM patients. MMR deficiency (dMMR) has been well described in several malignancies and was approved as a biomarker for anti-PD-1 inhibitors. Next generation sequencing (NGS) data demonstrated that 2% of MPM harbor microsatellite instability.
S. Cedrés, S. Ponce-Aix, P. Iranzo, A. Callejo, N. Pardo, A. Navarro, A. Martinez-Marti, S. Gómez-Abecia, A. C. Zucchiatti, I. Sansano, A. B. Enguita, J. M. Miquel, C. Viaplana, R. Dienstmann, L. Paz-Ares, E. Felip   +15 more
openaire   +2 more sources

The Immunohistochemistry Signature of Mismatch Repair (MMR) Proteins in a Multiethnic Asian Cohort With Endometrial Carcinoma

International Journal of Gynecological Pathology, 2014
Endometrial cancer is the most common gynecologic cancer in developed countries and is rising in incidence globally. Although the 5-year survival rates are >80%, factors beyond conventional pathologic features that predict clinical outcomes are still being elucidated.
Woo, Y.L., Cheah, P.L., Shahruddin, S.I., Omar, S.Z., Arends, M.   +4 more
openaire   +3 more sources

Somatic tumor profiling of DNA mismatch repair (MMR) deficient endometrial cancers (EC).

Journal of Clinical Oncology, 2017
e17121 Background: Approximately 20% of EC have loss of MMR ( MSH2, MSH6, MLH1, PMS2) protein expression by immunohistochemistry (IHC). The majority have somatic MLH1/PMS2 loss, driven by MLH1 promoter hypermethylation. For the remaining patients (pts), germline testing for Lynch Syndrome (LS) is recommended. However, half do not have a corresponding
Karen Anne Cadoo, Deborah DeLair, Diana Mandelker, Magan Trottier, Carolyn Stewart, Christina Tran, Yelena Kemel, Michael Francis Walsh, Felicia Scharf, David Michael Hyman, Vijai Joseph, Mark E. Robson, Nadeem Abu-Rustum, Kenneth Offit, David B. Solit, Michael F. Berger, Carol Aghajanian, Zsofia Kinga Stadler   +17 more
openaire   +1 more source

Prevalence of Mismatch Repair Gene Defects by Means of Immuno-histochemistry Staining for MMR Proteins in Endometrial Cancer

Journal of Obstetrics and Gynecology of India
In India, the incidence of uterine cancer is 17,420 per year. Presence of mismatch repair genes is one of the risk factors which can cause microsatellite instability in DNA leading to hereditary syndromes as well as sporadic cancer. In the present study, we aim to determine the prevalence of MMR gene mutations by IHC staining for MMR proteins in ...
Indu R Nair, Anupama Rajanbabu
exaly   +4 more sources

Clinical characterization of pancreatic ductal adenocarcinomas (PDAC) with mismatch repair (MMR) gene mutations.

Journal of Clinical Oncology, 2017
e15791 Background: Tumors with mismatch repair-deficiency (MMRD) have a high mutational burden and have good responses to immunotherapy (Le, NEJM, 2015). We describe the natural course, clinicopathological, and genomic status of MMRD PDAC patients (pts) at Memorial Sloan Kettering Cancer Center (MSKCC).
Zishuo Ian Hu, Anna M. Varghese, Jinru Shia, Alice Zervoudakis, Maeve Aine Lowery, Kenneth H. Yu, Sree Bhavani Chalasani, Mark E. Robson, Zsofia Kinga Stadler, Philip Caron, David Paul Kelsen, David Klimstra, Daniel W. Kelly, Eileen Mary O'Reilly   +13 more
openaire   +1 more source