Mismatch repair dependence of replication stress-associated DSB recognition and repair
Heliyon, 2019 Most cancers develop with one of two types of genomic instability, namely, chromosomal instability (CIN) or microsatellite instability (MSI). Both are induced by replication stress-associated DNA double-strand breaks (DSBs).
Haruka Fujimori +9 more
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Asian Pacific Journal of Cancer Biology, 2022 Background: DNA mismatch repair (MMR) is an important process during the DNA replication for correcting DNA replication errors. Deficient MMR (dMMR) leads to increased mutational burden and has been associated with several carcinomas and cancer syndromes
Kalita Lachit, Pant Vinita
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Cell death caused by single-stranded oligodeoxynucleotide-mediated targeted genomic sequence modification [PDF]
, 2009 Targeted gene repair directed by single-stranded oligodeoxynucleotides (ssODNs) offers a promising tool for biotechnology and gene therapy. However, the methodology is currently limited by its low frequency of repair events, variability, and low ...
Huang, JD +5 more
core +1 more source
Characterisation of the MutS and MutL Proteins from the Pseudomonas avellanae Mismatch Repair (MMR) System [PDF]
The Open Microbiology Journal, 2012 The identification and analysis of the Pseudomonas avellanae mismatch repair system (MMR) were performed via sequencing and cloning the mutS and mutL genes and then analyzing the characteristics of the ...
Grenga L +4 more
openaire +2 more sources
Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway. [PDF]
PLoS Genetics, 2013 Lynch syndrome (hereditary nonpolypsis colorectal cancer or HNPCC) is a common cancer predisposition syndrome. Predisposition to cancer in this syndrome results from increased accumulation of mutations due to defective mismatch repair (MMR) caused by a ...
Catherine E Smith +7 more
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A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803. [PDF]
, 2017 PurposeTumor levels of thymidylate synthase (TS), a target of 5-fluorouracil (5-FU)-based chemotherapy for colorectal cancer, have been studied as a predictive or prognostic biomarker with mixed results.Patients and methodsTumor TS levels were ...
Bertagnolli, Monica M +13 more
core +1 more source
Immunotherapy, Inflammation and Colorectal Cancer. [PDF]
, 2020 Colorectal cancer (CRC) is the third most common cancer type, and third highest in mortality rates among cancer-related deaths in the United States.
Karin, Michael +3 more
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Mismatch repair and repair of insertion/deletion loops in eukaryotic DNA
Acta Biomedica Scientifica, 2016 The mismatch repair (MMR) system detects non-Watson - Crick base pairs as well as the defects, appearing in course of DNA replication, and helps to eliminate them by catalyzing the excision of the defect-containing region of daughter DNA and its error ...
L. O. Gutsol +4 more
doaj +1 more source
Does sex of the patient play a role in survival for MSI colorectal cancer? [PDF]
, 2018 Microsatellite instability (MSI) is a feature of colorectal tumors that develops as a result of inactivation of the DNA mismatch repair system. It is found in about 15% of all colorectal cancers and is an important prognostic molecular marker when ...
Alecu, Lucian +11 more
core +3 more sources
Risk of Metachronous Colorectal Cancer in Lynch Syndrome: Who Needs an Extended Resection?
Surgeries, 2022 Lynch syndrome (LS) is the most common genetic condition associated with early-onset colorectal cancer. It is inherited in an autosomal dominant fashion.
Johannes Doerner
doaj +1 more source