Results 41 to 50 of about 42,721 (245)

Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-β in colorectal cells. [PDF]

, 2012
Estrogen has anti-colorectal cancer effects which are thought to be mediated by mismatch repair gene (MMR) activity. Estrogen receptor (ER) expression is associated with microRNA (miRNA) expression in ER-positive tumors.
Fu, Lei, He, Yu-qi, Jin, Peng, Ling, Xian-long, Rao, Jianyu, Sheng, Jian-qiu, Yen, Lawrence   +6 more
core   +1 more source

DNA mismatch repair (MMR)‐dependent 5‐fluorouracil cytotoxicity and the potential for new therapeutic targets [PDF]

British Journal of Pharmacology, 2009
The metabolism and efficacy of 5‐fluorouracil (FUra) and other fluorinated pyrimidine (FP) derivatives have been intensively investigated for over fifty years. FUra and its antimetabolites can be incorporated at RNA‐ and DNA‐levels, with RNA level incorporation provoking toxic responses in human normal tissue, and DNA‐level antimetabolite formation and
Long Shan, Li, Julio C, Morales, Martina, Veigl, David, Sedwick, Sheldon, Greer, Mark, Meyers, Mark, Wagner, Richard, Fishel, David A, Boothman   +8 more
openaire   +2 more sources

Mismatch repair balances leading and lagging strand DNA replication fidelity.

PLoS Genetics, 2012
The two DNA strands of the nuclear genome are replicated asymmetrically using three DNA polymerases, α, δ, and ε. Current evidence suggests that DNA polymerase ε (Pol ε) is the primary leading strand replicase, whereas Pols α and δ primarily perform ...
Scott A Lujan, Jessica S Williams, Zachary F Pursell, Amy A Abdulovic-Cui, Alan B Clark, Stephanie A Nick McElhinny, Thomas A Kunkel   +6 more
doaj   +1 more source

Evaluation of a tumor microenvironment-based prognostic score in primary operable colorectal cancer [PDF]

, 2015
Purpose: The tumor microenvironment is recognized as an important determinant of progression and outcome in colorectal cancer. The aim of the present study was to evaluate a novel tumor microenvironment–based prognostic score, based on histopathologic ...
Edwards, Joanne, Horgan, Paul G., McMillan, Donald C., Park, James H., Powell, Arfon G., Richards, Colin H., Roxburgh, Campbell S.D.   +6 more
core   +1 more source

Impact of mismatch repair (MMR) status on recurrence in high intermediate risk endometrial cancer [PDF]

Gynecologic Oncology
Approximately 25 % of endometrial cancers harbor deficiencies in mismatch repair (dMMR). The clinical impact of this molecular aberration remains undefined in patients with high intermediate risk (HIR) endometrial cancer.We conducted a retrospective chart review of women diagnosed with Stage I high-intermediate risk endometrioid endometrial cancer in ...
Keverline, Kelsey Jean, Hill, Breana, Hom-Tedla, Marianne, Jacobs, Marni, Eskander, Ramez N   +4 more
openaire   +3 more sources

DNA mismatch repair interacts with CAF-1- and ASF1A-H3-H4-dependent histone (H3-H4)2 tetramer deposition. [PDF]

, 2016
DNA mismatch repair (MMR) is required for the maintenance of genome stability and protection of humans from several types of cancer. Human MMR occurs in the chromatin environment, but little is known about the interactions between MMR and the chromatin ...
Kadyrov, Farid A, Kadyrova, Lyudmila Y, Rodriges Blanko, Elena   +2 more
core   +2 more sources

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

eLife, 2015
To avoid mutations in the genome, DNA replication is generally followed by DNA mismatch repair (MMR). MMR starts when a MutS homolog recognizes a mismatch and undergoes an ATP-dependent transformation to an elusive sliding clamp state. How this transient
Flora S Groothuizen, Ines Winkler, Michele Cristóvão, Alexander Fish, Herrie HK Winterwerp, Annet Reumer, Andreas D Marx, Nicolaas Hermans, Robert A Nicholls, Garib N Murshudov, Joyce HG Lebbink, Peter Friedhoff, Titia K Sixma   +12 more
doaj   +1 more source

Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae

Nature Communications, 2021
Defects in DNA mismatch repair (MMR) have been linked to inherited and sporadic cancers. Here the authors demonstrate that the DNA repair protein Rad27 (human FEN1) functions in one of three redundant mispair excision pathways, where its flap ...
Felipe A. Calil, Bin-Zhong Li, Kendall A. Torres, Katarina Nguyen, Nikki Bowen, Christopher D. Putnam, Richard D. Kolodner   +6 more
doaj   +1 more source

Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: Genetic reclassification and correlation with clinical features [PDF]

, 2004
Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder predisposing to predominantly colorectal cancer (CRC) and endometrial cancer frequently due to germline mutations in DNA mismatch repair (MMR) genes, mainly ...
Baretton, G., Daum, J., Gross, M., Holinski-Feder, E., Kopp, R., Lohse, P., Muders, M., Mussack, T., Müller-Koch, Y., Schiemann, Uwe   +9 more
core   +1 more source

The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

Nature Communications, 2020
DNA mismatch repair (MMR)-deficient cancers with microsatellite-instability are characterized by a high load of frameshift mutation-derived neoantigens. Here, by mapping the frameshift mutation landscape and predicting the immunogenicity of the resulting
Alexej Ballhausen, Moritz Jakob Przybilla, Michael Jendrusch, Saskia Haupt, Elisabeth Pfaffendorf, Florian Seidler, Johannes Witt, Alejandro Hernandez Sanchez, Katharina Urban, Markus Draxlbauer, Sonja Krausert, Aysel Ahadova, Martin Simon Kalteis, Pauline L. Pfuderer, Daniel Heid, Damian Stichel, Johannes Gebert, Maria Bonsack, Sarah Schott, Hendrik Bläker, Toni Seppälä, Jukka-Pekka Mecklin, Sanne Ten Broeke, Maartje Nielsen, Vincent Heuveline, Julia Krzykalla, Axel Benner, Angelika Beate Riemer, Magnus von Knebel Doeberitz, Matthias Kloor   +29 more
doaj   +1 more source