Results 201 to 210 of about 620,845 (342)

Effectiveness and safety of interventions for fever‐associated discomfort in children: A systematic review

British Journal of Clinical Pharmacology, EarlyView.
Aims Fever is one of the most frequent reasons for paediatric consultations. While traditionally managed by reducing body temperature, recent guidelines emphasize alleviating discomfort as the primary therapeutic goal. Although different interventions have been described to manage fever‐associated discomfort in children, their effectiveness and safety ...
Antonio Corsello, Ilaria Alberti, Sara Farhanghi, Alessia Bonetti, Silvia Garattini, Anna Comotti, Paola Marchisio, Elena Chiappini, Gregorio Paolo Milani   +8 more
wiley   +1 more source

Risky or rigorous? Developing trustworthiness criteria for AI‐supported qualitative data analysis

Anatomical Sciences Education, EarlyView.
Michelle D. Lazarus, Linxuan Zhao, Andrew Gibson, Roberto Martinez‐Maldonado, Georgina C. Stephens   +4 more
wiley   +1 more source

Why and how do we perform physical examination(s) in clinical trials? A use case of drug intervention trials in type 2 diabetes mellitus

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this study was to determine the purpose and use of physical examination (PE) in phase 3 and 4 drug interventional clinical trials within type 2 diabetes mellitus. Methods A total of 226 clinical trial protocols identified from the ClinicalTrials.gov database were systematically reviewed by five researchers.
Julia Kopanz, Amy Rogers, Lina Pérez‐Breva, Emily Hall, Prashasthi Devaiah, Isla S. Mackenzie, Bart Lagerwaard, Diederick E. Grobbee, Mira G. P. Zuidgeest, on behalf of the Trials@Home consortium   +9 more
wiley   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding, Richard M. Hoglund, Rob W. van der Pluijm, James J. Callery, Thomas J. Peto, Rupam Tripura, Sukanta Das, Nguyễn Hoàng Châu, Cholrawee Promnarate, Mavuto Mukaka, Lek Dysoley, Caterina Fanello, Marie A. Onyamboko, Anupkumar R. Anvikar, Mayfong Mayxay, Frank Smithuis, Lorenz von Seidlein, Mehul Dhorda, Chanaki Amaratunga, M. Abul Faiz, Ho Dang Trung Nghia, Nicholas J. White, Nicholas P. J. Day, Arjen M. Dondorp, Joel Tarning   +24 more
wiley   +1 more source

String Figuring young children's perspectives of quality in English early childhood education and care

British Educational Research Journal, EarlyView.
Abstract Quality in early childhood education and care (ECEC) is a contested concept and has generally been conceptualised by inter‐related indicators such as staff qualifications, educational environment, policy or child‐to‐staff ratios. There has been a more limited emphasis on how young children might perceive and experience quality.
Nikki Fairchild, Éva Mikuska
wiley   +1 more source

Missed Nursing Care Infection Prevention and Control Practices in Acute Hospitals in Ireland During the COVID-19 Pandemic. [PDF]

Int J Nurs Pract
Kirwan M, Egan E, Matthews A.
europepmc   +1 more source

Engineering habits of mind in preschool children at Scottish forest nurseries and Australian bush kinders

British Educational Research Journal, EarlyView.
Abstract Nature‐based learning environments for early childhood are expanding, as is research into their affordances and pedagogies. Engineering in these environments is not well studied. Previous work considered engineering experiences through the lens of ‘designerly play’, finding that natural materials, the space for larger creations and ...
Rebecca Donnelly, Chris Speldewinde, Helen Bridle   +2 more
wiley   +1 more source

Association Between Missed Nursing Care and Nurse Fatigue: A Cross-Sectional Correlational Study. [PDF]

Nurs Rep
Alshammari B, Alsaleh GS, Alrasheeday A, Baghdadi N, Almalki N, Alshammari F, Assiry A, Almalki M.   +7 more
europepmc   +1 more source

Graduates' conceptions of meaningful work

British Educational Research Journal, EarlyView.
Abstract This paper explores how meaningful work is conceptualised by recent graduates. Whilst the imperative to maximise economic returns from higher education (HE) endures in HE policy, less attention is given to how meaningful work is and its relationship to values and identities.
Michael Tomlinson, Manuel Souto‐Otero
wiley   +1 more source