Results 231 to 240 of about 2,011,733 (296)

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Missed Opportunities in Tuberculosis (TB) Prevention in Pediatric Population: A Retrospective Observational Study From North India. [PDF]

Cureus
Kumari S, Agarwal A, Singh M, Grover K, Chandra J, Yadav TP.   +5 more
europepmc   +1 more source

Asymmetric Single‐Atom Catalysts Govern Diffusible and Non‐Diffusible Non‐Radical Pathways for Selective Degradation of Antibiotic Resistance Genes

Advanced Science, EarlyView.
Asymmetric single‐atom metal‐nitrogen‐carbon catalysts modulate the non‐radical pathway during peroxymonosulfate (PMS) activation. A fundamental contrast was revealed between diffusible singlet oxygen (1O2) and non‐diffusible electron‐transfer pathways (ETP) in antibiotic resistance gene (ARG) degradation.
Chen Gao, Jun Sun, Liang Zhang, Litao Lin, Zongfeng Wan, Bingcai Pan, Sheng Tang   +6 more
wiley   +1 more source

Latent Diffusion Process With Mechanistic Guidance For Designing Functionally Graded Metamaterials With Perfect Connectivity

Advanced Science, EarlyView.
A latent diffusion‐based framework is proposed for designing functionally graded metamaterials with perfect connectivity. By integrating vector‐quantized latent representations with mechanistic guidance, the framework enables accurate inverse design toward target elastic properties.
Jongbin Yu, Dosung Lee, Namjung Kim
wiley   +1 more source

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

Advanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal, Ronald Garcia, Guangyi Chen, Chantal D. Bader, Peter Sullivan, Alexander Popoff, Daniel Krug, Maja Hunter, Sebastian Walesch, Emilia Oueis, Christine Frank, Haowen Zhao, Joachim J. Hug, Sebastian Keller, Pascal Hirsch, Azat Tagirdzhanov, Tatiana Malygina, Mary Victory E. Gutierrez, Alexey Gurevich, Judith Boldt, Boyke Bunk, Jörg Overmann, Ulrich Nübel, Andreas Keller, Olga V. Kalinina, Rolf Müller   +25 more
wiley   +1 more source

Disability, disclosure, and missed opportunities: a qualitative study of perinatal intimate partner violence screening. [PDF]

BMC Pregnancy Childbirth
Alhusen JL, Hughes RB, Laughon K, Prevete J, McDonald M.   +4 more
europepmc   +1 more source

Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming

Advanced Science, EarlyView.
Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du, Zhixiang Niu, Yanfen Wang, Shirui Zhou, Youqing Yang, Xiang Wei, Haishan Niu, Yitao Zhang, Anquan Xia, Yali Liu, Yanbin Hao, Kai Xue, Bingfang Wu, Xinquan Zhao, Tandong Yao, Yiyu Chen   +15 more
wiley   +1 more source

Missed Opportunities for HIV Testing in Hospitalised Adults in Türkiye: Indicator Conditions and Testing Coverage in a National Multicentre Point-Prevalence Survey (HIV-ICs-TR). [PDF]

Sci Rep
Çiçek Y, Çelen MK, Pullukçu H, Büyüktuna SA, Can FK, Ertürk D, Sengel BE, Parlayan HNK, Yıldız İE, Özden K, Alay H, Albayrak A, Seçkin DA, Erdoğan G, İrdem T, Gülçek BS, Okul K, Kaya D, Tol C, Özkara MB, Ceylan M, Acet O, Öksüz C, Karaarslan R, Aslanoğlu ZPY, Dağcı Eİ, Kömür S, Demir S, Yardımcı ÖF, Çolak GM, Zakaradze D, Kalyoncu ED, Ocak B, Yılmaz G, Koç AT, Kaya A, Özdemir MN, Kurutaş GÖ, İlgar T, Özşahin A, Mahmutoğlu-Çolak S, Beşbaş K, Taşova Y.   +42 more
europepmc   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Missed opportunities in post-total knee arthroplasty rehabilitation in Indonesia: a narrative review of insurance-driven delays in functional recovery. [PDF]

Front Rehabil Sci
Waluyo Y, Sam N, Mikami Y, Hamdi FR.
europepmc   +1 more source