Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Multiple imputation of missing data under missing at random: compatible imputation models are not sufficient to avoid bias if they are mis-specified. [PDF]
J Clin Epidemiol, 2023 Curnow E +7 more
europepmc +1 more source
Latent Class Models for Longitudinal Studies of the Elderly with Data Missing at Random [PDF]
, 2002 Beth A. Reboussin +3 more
openalex +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Sample size calculation for randomized trials via inverse probability of response weighting when outcome data are missing at random. [PDF]
Stat Med, 2023 Harrison LJ, Wang R.
europepmc +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Analyzing the changing gender wage gap based on multiply imputed right censored wages [PDF]
"In order to analyze the gender wage gap with the German IAB-employment sample we have to solve the problem of censored wages at the upper limit of the social security system. We treat this problem as a missing data problem.
Gartner, Hermann, Rässler, Susanne
core
Linear mixed models to handle missing at random data in trial-based economic evaluations. [PDF]
Health Econ, 2022 Gabrio A +3 more
europepmc +1 more source
A Novel Two Tier Missing at Random Type Missing Data Imputation using Enhanced Linear Interpolation Technique on Internet of Medical Things [PDF]
, 2023 P. Iris Punitha, J.G.R. Sathiaseelan
openalex +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source