Results 51 to 60 of about 764,403 (277)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
A real data-driven simulation strategy to select an imputation method for mixed-type trait data.
PLoS Computational Biology, 2023 Missing observations in trait datasets pose an obstacle for analyses in myriad biological disciplines. Considering the mixed results of imputation, the wide variety of available methods, and the varied structure of real trait datasets, a framework for ...
Jacqueline A May +2 more
doaj +1 more source
An Investigation of Missing Data Methods for Classification Trees [PDF]
, 2008 There are many different missing data methods used by classification tree algorithms, but few studies have been done comparing their appropriateness and performance.
Ding, Yufeng, Simonoff, Jeffrey S.
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Semiparametric inference of competing risks data with additive hazards and missing cause of failure under MCAR or MAR assumptions [PDF]
, 2014 International audienceIn this paper, we consider a semiparametric model for lifetime data with competing risks and missing causes of death. We assume that an additive hazards model holds for each cause-specific hazard rate function and that a random ...
Bordes, Laurent +2 more
core +3 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Missing values: sparse inverse covariance estimation andanextension to sparse regression [PDF]
, 2018 We propose an ℓ 1-regularized likelihood method for estimating the inverse covariance matrix in the high-dimensional multivariate normal model in presence of missing data.
Bühlmann, Peter, Städler, Nicolas
core
Statistical inference for hardy-weinberg proportions in the presence of missing genotype information [PDF]
, 2016 In genetic association studies, tests for Hardy-Weinberg proportions are often employed as a quality control checking procedure. Missing genotypes are typically discarded prior to testing.
Cook, Samantha +3 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
ON THE POTENTIAL FOR ILL-LOGIC WITH LOGICALLY DEFINED OUTCOMES [PDF]
, 2006 Logically defined outcomes are commonly used in medical diagnoses and epidemiological research. When missing values in the original outcomes exist, the method of handling the missingness can have unintended consequences, even if the original outcomes ...
Caffo, Brian S. +2 more
core +1 more source