Results 211 to 220 of about 998,037 (295)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Reported Neurologic Manifestations Among Persons With Syphilis by Stage of Infection-12 States, 2019-2022. [PDF]

Clin Infect Dis
Wondmeneh SB, McDonald R, Quilter LAS, Workowski KA, Torrone EA, Jackson DA.   +5 more
europepmc   +1 more source

The Strengths and Limitations of South Africa's Search for Apartheid-Era Missing Persons. [PDF]

Int J Transit Justice, 2011
Aronson JD.
europepmc   +1 more source

High risk?:attitudes to the risk assessment process in missing person investigations [PDF]

, 2014
Shalev Greene, Karen, Smith, Richard
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Disability severity transitions in the community-dwelling Swiss ageing population: secondary analysis of the Swiss version of the Survey of Health, Ageing and Retirement in Europe (SHARE) using multistate models. [PDF]

BMJ Open
Hodel J, Rothacher Y, Moreira B, Fellinghauer C, Pacheco Barzallo D, Weisstanner D, Ehrmann C, Sabariego C.   +7 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Homicides of American Indians/Alaska Natives in urban versus rural areas: United States National Violent Death Reporting System, 2003-2020. [PDF]

Inj Prev
Corry DT, Kollar LMM, Betz CJ, Fowler KA, Kearns MC, Smith SG, Satter DE.   +6 more
europepmc   +1 more source

Missing children and adults : a cross government strategy [PDF]

, 2011

core