Results 201 to 210 of about 16,362,739 (323)

Investigation of Seasonal Variation in Fatty Acid and Mineral Concentrations of Pecorino Romano PDO Cheese: Imputation of Missing Values for Enhanced Classification and Metabolic Profile Reconstruction. [PDF]

Metabolites, 2023
Sibono L, Grosso M, Tronci S, Errico M, Addis M, Vacca M, Manis C, Caboni P.   +7 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

XeroGraph: enhancing data integrity in the presence of missing values with statistical and predictive analysis. [PDF]

Bioinform Adv
Mousafi Alasal L, Hammarlund EU, Pienta KJ, Rönnstrand L, Kazi JU.   +4 more
europepmc   +1 more source

Practical guidance to handle missing values in the 25-question Geriatric Locomotive Function Scale (GLFS-25): a simulation study. [PDF]

BMJ Open, 2022
Kawahara T, Yamada K, Terashima R, Takashima I, Tanaka S, Ogata T, Chikuda H, Miura H, Nakamura K, Ohe T.   +9 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Handling missing values in patient-reported outcome data in the presence of intercurrent events. [PDF]

BMC Med Res Methodol
Thomassen D, Roychoudhury S, Amdal CD, Reynders D, Musoro JZ, Sauerbrei W, Goetghebeur E, le Cessie S, SISAQOL-IMI Work Package 3.   +8 more
europepmc   +1 more source

HarmonizR enables data harmonization across independent proteomic datasets with appropriate handling of missing values. [PDF]

Nat Commun, 2022
Voß H, Schlumbohm S, Barwikowski P, Wurlitzer M, Dottermusch M, Neumann P, Schlüter H, Neumann JE, Krisp C.   +8 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Using set visualisation to find and explain patterns of missing values: a case study with NHS hospital episode statistics data. [PDF]

BMJ Open, 2022
Ruddle RA, Adnan M, Hall M.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source