Results 121 to 130 of about 16,381 (262)

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source

Are Academic Executives Greener? Evidence From China

Managerial and Decision Economics, EarlyView.
ABSTRACT This paper investigates the impact of executives with academic backgrounds (“academic executives”) on corporate green patents. We find that both the presence of academic executives and the proportion of academic executives have a significantly positive impact on firms' green patents, and this effect is positively associated with the firm's ...
Kai Xing, Xiong Li, Ping Liu, Hanxiong Zhang, Yuhan Xiao   +4 more
wiley   +1 more source

Using recurrent neural network to estimate irreducible stochasticity in human choice behavior

eLife
Theoretical computational models are widely used to describe latent cognitive processes. However, these models do not equally explain data across participants, with some individuals showing a bigger predictive gap than others.
Yoav Ger, Moni Shahar, Nitzan Shahar
doaj   +1 more source

A Cautionary Tale of Model Misspecification and Identifiability

Bulletin of Mathematical Biology
Mathematical models are routinely applied to interpret biological data, with common goals that include both prediction and parameter estimation. A challenge in mathematical biology, in particular, is that models are often complex and non-identifiable, while data are limited.
Alexander P. Browning, Jennifer A. Flegg, Ryan J. Murphy   +2 more
openaire   +3 more sources

Optimal Designs and Inspection Time Decisions for Gamma Accelerated Degradation Tests

Naval Research Logistics (NRL), EarlyView.
ABSTRACT This study analytically derives optimal designs for gamma accelerated degradation tests while incorporating inspection time as a design variable under both D‐ and V‐optimality criteria. Under D‐optimality, we prove that the optimal design allocates test units exclusively to the lowest and highest stress levels and adopts the longest inspection
Hung‐Ping Tung, I‐Chen Lee
wiley   +1 more source

A recipe for recovery: diet as a decisive tool in species conservation

Oikos, EarlyView.
Animals consume foods in specific quantities and ratios to meet a multi‐dimensional nutrient target that maximizes their fitness. Attempts to reach this target in an ever‐changing nutritional landscape often influence animal foraging behavior, habitat choice, and food‐web interactions. Consequently, understanding the nutritional ecology of a species is
Noa Lavie, Yael Levinson, Jessica M. Rothman, Dror Hawlena   +3 more
wiley   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

Model Misspecification [PDF]

, 2015
Moosa, I., Burns, Kelly
openaire   +2 more sources

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source